ArticleACS applied materials & interfaces2016
Light-Responsive Biodegradable Nanomedicine Overcomes Multidrug Resistance via NO-Enhanced Chemosensitization.
Article in ACS applied materials & interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance.Apoptosis : an international journal on programmed cell death · 2022Pooled it
- A 'frost formation'-inspired near-infrared-responsive nitric oxide-releasing hydrogel for enhancing fat graft survival.Regenerative biomaterials · 2026Article
- Nanomaterials-Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Therapeutic functions of medical implants from various material categories with integrated biomacromolecular systems.Frontiers in bioengineering and biotechnology · 2024Review
- A review of advanced hydrogels for cartilage tissue engineering.Frontiers in bioengineering and biotechnology · 2024Review
- Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy.Smart medicine · 2023Article
- NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy.Biosensors · 2023Article
- Molecularly self-fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke.Nature communications · 2023Article
- Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy.Pharmaceutics · 2021Review
- Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy.Bioactive materials · 2021Article
- Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance.Theranostics · 2021Review
- Recent progress in nanomedicine for enhanced cancer chemotherapy.Theranostics · 2021Review
- Strategies for engineering advanced nanomedicines for gas therapy of cancer.National science review · 2020Article
- Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges.Antioxidants (Basel, Switzerland) · 2020Review
- Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy.Nano-micro letters · 2020Article
- Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing.Chemical science · 2020Article
- Stimuli-Responsive Drug Release from Smart Polymers.Journal of functional biomaterials · 2019Review
- Controlled Delivery of Nitric Oxide for Cancer Therapy.Pharmaceutical nanotechnology · 2019Review
- Local generation of hydrogen for enhanced photothermal therapy.Nature communications · 2018Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Multidrug resistance (MDR) is responsible for the relatively low effectiveness of chemotherapeutics. Herein, a nitric oxide (NO) gas-enhanced chemosensitization strategy is proposed to overcome MDR by construction of a biodegradable nanomedicine formula based on BNN6/DOX coloaded monomethoxy(polyethylene glycol)-poly(lactic-co-glycolic acid) (mPEG-PLGA). On one hand, the nanomedicine features high biocompatibility due to the high density of PEG and biodegradable PLGA. On the other hand, the nanoformula exhibits excellent stability under physiological conditions but exhibits stimuli-responsive decomposition of BNN6 for NO gas release upon ultraviolet-visible irradiation. More importantly, after NO release is triggered, gas molecules are generated that break the nanoparticle shell and lead to the release of doxorubicin. Furthermore, NO was demonstrated to reverse the MDR of tumor cells and enhance the chemosensitization for doxorubicin therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.