ArticleAnalytical chemistry2016
Mass Spectrometric Collisional Activation and Product Ion Mobility of Human Serum Neutral Lipid Extracts.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- [Applications of ion mobility-mass spectrometry in the chemical analysis in traditional Chinese medicines].Se pu = Chinese journal of chromatography · 2022Review
- Prediction of Collision Cross Section Values: Application to Non-Intentionally Added Substance Identification in Food Contact Materials.Journal of agricultural and food chemistry · 2022Article
- A Novel Approach to Characterize the Lipidome of Marine ArchaeonFrontiers in microbiology · 2021Article
- Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging.Rapid communications in mass spectrometry : RCM · 2020Article
- Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis.Journal of the American Society for Mass Spectrometry · 2019Article
- Challenges in Mass Spectrometry-based Lipidomics of Neutral Lipids.Trends in analytical chemistry : TRAC · 2018Article
- Tandem Mass Spectrometry and Ion Mobility Reveals Structural Insight into Eicosanoid Product Ion Formation.Journal of the American Society for Mass Spectrometry · 2018Article
- Improving the discovery of secondary metabolite natural products using ion mobility-mass spectrometry.Current opinion in chemical biology · 2018Review
- Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic, and type 2 diabetic individuals.GigaScience · 2017Article
- Tandem Mass Spectrometry in Combination with Product Ion Mobility for the Identification of Phospholipids.Analytical chemistry · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A novel method for lipid analysis called CTS (collisional activation and traveling wave mass spectrometry), involving tandem mass spectrometry of all precursor ions with ion mobility determinations of all product ions, was applied to a sample of human serum. The resulting four-dimensional data set (precursor ion, product ion, ion mobility value, and intensity) was found to be useful for characterization of lipids as classes as well as for identification of specific species. Utilization of ion mobility measurements of the product ions is a novel approach for lipid analysis. The trends and patterns of product mobility values when visually displayed yield information on lipid classes and specific species independent of mass determination. Collection of a comprehensive set of data that incorporates all precursor-product relationships, combined with ion mobility measurements of all products, enables data analysis where different molecular properties can be juxtaposed and analyzed to assist with class and species identification. Overall, CTS is a powerful, specific, and comprehensive method for lipid analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.