Evidence map›Paper›PMID 27213366›Full record

ReviewInternational journal of molecular sciences2016

Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria.

Annarita Falanga, Lucia Lombardi, Gianluigi Franci, Mariateresa Vitiello, Maria Rosaria Iovene, Giancarlo Morelli, Massimiliano Galdiero, Stefania Galdiero

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. A MarineMarine drugs · 2026
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  4. ACS omega · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annarita FalangaDepartment of Pharmacy, CIRPEB-University of Naples "Federico II", Via Mezzocannone 16, 80134 Napoli, Italy. annarita.falanga@unina.it.
Lucia LombardiDepartment of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Napoli, Italy. lucia.lombardi@unina2.it.
Gianluigi FranciDepartment of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Napoli, Italy. gianluigi.franci@yahoo.it.
Mariateresa VitielloDepartment of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Napoli, Italy. mteresa.vitiello@unina2.it.
Maria Rosaria IoveneDepartment of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Napoli, Italy. MariaRosaria.IOVENE@unina2.it.
Giancarlo MorelliDepartment of Pharmacy, CIRPEB-University of Naples "Federico II", Via Mezzocannone 16, 80134 Napoli, Italy. giancarlo.morelli@unina.it.
Massimiliano GaldieroDepartment of Experimental Medicine, II University of Naples, Via De Crecchio 7, 80138 Napoli, Italy. massimiliano.galdiero@unina2.it.
Stefania GaldieroDepartment of Pharmacy, CIRPEB-University of Naples "Federico II", Via Mezzocannone 16, 80134 Napoli, Italy. stefania.galdiero@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery of antibiotics for the treatment of bacterial infections brought the idea that bacteria would no longer endanger human health. However, bacterial diseases still represent a worldwide treat. The ability of microorganisms to develop resistance, together with the indiscriminate use of antibiotics, is mainly responsible for this situation; thus, resistance has compelled the scientific community to search for novel therapeutics. In this scenario, antimicrobial peptides (AMPs) provide a promising strategy against a wide array of pathogenic microorganisms, being able to act directly as antimicrobial agents but also being important regulators of the innate immune system. This review is an attempt to explore marine AMPs as a rich source of molecules with antimicrobial activity. In fact, the sea is poorly explored in terms of AMPs, but it represents a resource with plentiful antibacterial agents performing their role in a harsh environment. For the application of AMPs in the medical field limitations correlated to their peptide nature, their inactivation by environmental pH, presence of salts, proteases, or other components have to be solved. Thus, these peptides may act as templates for the design of more potent and less toxic compounds.

Indexed as

AnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesAquatic OrganismsBacteriaDrug Resistance, BacterialHumansProtein Structure, SecondaryAnti-Infective AgentsAntimicrobial Cationic Peptidesantimicrobial peptidemarine AMPsmembrane bilayermicrobial resistance

Identifiers

PMID27213366
PMCPMC4881601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.