ArticleNature genetics2016
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.
Abstract readComparative Study
In one paragraph
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.
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117citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
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Who cites it
117 citing papers in PubMed, 1 synthesis or guideline pooled it, 224 citations in OpenAlex.
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- A Comprehensive HLA-DR4 MHC Class II Tetramer Platform for the Detection and Functional Validation of Post-Translational Modification Neoantigens.International journal of molecular sciences · 2026Article
- [Role of HLA genetic variants in autoimmune diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Clinical applications and methodology updates in HLA typing.BMC immunology · 2026Review
- High-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant.Nature communications · 2026Article
- Factors influencing quality of life in patients with psoriasis: A large cross-sectional study.Chinese medical journal · 2026Article
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- B Cells Can Trigger the T-Cell-Mediated Autoimmune Response Against Melanocytes in Psoriasis.Cells · 2025Article
- Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.Cell genomics · 2025Article
- Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis.Nature communications · 2025Article
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- A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population.Diabetologia · 2025Article
- Uncovering genetic diversity and admixture of British Africans with HLA alleles inferred from whole genome sequencing.European journal of human genetics : EJHG · 2025Article
57 more citing papers are in PubMed but not listed here.
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Authors and funding
73 authors at 11 institutions in 7 countries.
Fusheng ZhouDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Hongzhi CaoBGI-Shenzhen, Shenzhen, China.
Xianbo ZuoDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Tao ZhangBGI-Shenzhen, Shenzhen, China.
Xiaoguang ZhangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xiaomin LiuBGI-Shenzhen, Shenzhen, China.ORCID 0000-0003-2155-3627
Ricong XuDepartment of Nephrology, First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, China.
Gang ChenDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Yuanwei ZhangBGI-Shenzhen, Shenzhen, China.
Xiaodong ZhengDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xin JinBGI-Shenzhen, Shenzhen, China.
Jinping GaoDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Junpu MeiBGI-Shenzhen, Shenzhen, China.
Yujun ShengDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Qibin LiBGI-Shenzhen, Shenzhen, China.
Bo LiangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Juan ShenBGI-Shenzhen, Shenzhen, China.
Changbing ShenDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Hui JiangBGI-Shenzhen, Shenzhen, China.
Caihong ZhuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xing FanDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Fengping XuBGI-Shenzhen, Shenzhen, China.
Min YueDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xianyong YinDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Chen YeBGI-Shenzhen, Shenzhen, China.
Cuicui ZhangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xiao LiuBGI-Shenzhen, Shenzhen, China.
Liang YuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Jinghua WuBGI-Shenzhen, Shenzhen, China.
Mengyun ChenDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xuehan ZhuangBGI-Shenzhen, Shenzhen, China.
Lili TangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Haojing ShaoBGI-Shenzhen, Shenzhen, China.
Longmao WuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Jian LiBGI-Shenzhen, Shenzhen, China.
Yu XuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Yijie ZhangBGI-Shenzhen, Shenzhen, China.
Suli ZhaoDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Yu WangBGI-Shenzhen, Shenzhen, China.
Ge LiDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Hanshi XuBGI-Shenzhen, Shenzhen, China.
Lei ZengDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Jianan WangBGI-Shenzhen, Shenzhen, China.
Mingzhou BaiBGI-Shenzhen, Shenzhen, China.
Yanling ChenBGI-Shenzhen, Shenzhen, China.
Wei ChenBGI-Shenzhen, Shenzhen, China.
Tian KangBGI-Shenzhen, Shenzhen, China.
Yanyan WuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xun XuBGI-Shenzhen, Shenzhen, China.
Zhengwei ZhuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Yong CuiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Zaixing WangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Chunjun YangDepartment of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, China.
Peiguang WangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Leihong XiangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xiang ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Anping ZhangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Xinghua GaoDepartment of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.
Furen ZhangShandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China.
Jinhua XuDepartment of Dermatology, Huashan Hospital and Collaborative Innovation Center of Complex and Severe Skin Disease, Fudan University, Shanghai, China.
Min ZhengDepartment of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jie ZhengDepartment of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Jianzhong ZhangDepartment of Dermatology, Peking University People's Hospital, Beijing, China.
Xueqing YuDepartment of Nephrology, First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, China.
Yingrui LiBGI-Shenzhen, Shenzhen, China.
Sen YangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Huanming YangBGI-Shenzhen, Shenzhen, China.
Jian WangBGI-Shenzhen, Shenzhen, China.
Jianjun LiuDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Lennart HammarströmBGI-Shenzhen, Shenzhen, China.
Liangdan SunDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Jun WangBGI-Shenzhen, Shenzhen, China.
Xuejun ZhangDepartment of Dermatology, No. 1 Hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
Anhui Medical University · CNBGI Group (China) · CNSun Yat-sen University · CNCentral South University · CNChina-Japan Friendship Hospital · CNChina Medical University · CNFudan University · CNPeking University · CNRuijin Hospital · CNSecond Affiliated Hospital of Zhejiang University · CNShandong Provincial Institute of Dermatology and Venereology · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy. We further identified multiple independent new susceptibility loci in HLA-C, HLA-B, HLA-DPB1 and BTNL2 and an intergenic variant, rs118179173, associated with psoriasis and confirmed the well-established risk allele HLA-C*06:02. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance understanding of the pathogenesis of these disorders.
Indexed as
Asian PeopleButyrophilinsCase-Control StudiesChinaGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHLA-B AntigensHLA-C AntigensHLA-DP beta-ChainsHumansMajor Histocompatibility ComplexPolymorphism, Single NucleotidePsoriasisBTNL2 protein, humanButyrophilinsHLA-B AntigensHLA-C AntigensHLA-DPB1 antigenHLA-DP beta-Chains
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