Evidence map›Paper›PMID 27213278›Full record

ArticleProtein science : a publication of the Protein Society2016

TRIC: Capturing the direct cellular targets of promoter-bound transcriptional activators.

Amanda Dugan, Rachel Pricer, Micah Katz, Anna K Mapp

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amanda DuganLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Rachel PricerLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Micah KatzLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Anna K MappLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Environmental Research Institute of Michigan · USUniversity of Michigan–Ann Arbor · US

Funding

MICHIGAN CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008597 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONTGOMERY, JOHN · 1996 to 2018
$5.0M
NIGMS NIH HHS T32 GM008597
6 · The paper itself

Abstract

Transcriptional activators coordinate the dynamic assembly of multiprotein coactivator complexes required for gene expression to occur. Here we combine the power of in vivo covalent chemical capture with p-benzoyl-L-phenylalanine (Bpa), a genetically incorporated photo-crosslinking amino acid, and chromatin immunoprecipitation (ChIP) to capture the direct protein interactions of the transcriptional activator VP16 with the general transcription factor TBP at the GAL1 promoter in live yeast.

Indexed as

Transcriptional ActivationBenzophenonesChromatin ImmunoprecipitationCross-Linking ReagentsGalactokinaseHerpes Simplex Virus Protein Vmw65PhenylalaninePhotochemical ProcessesPromoter Regions, GeneticProtein BindingProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionTATA-Box Binding ProteinTrans-Activators4-benzoylphenylalanineBenzophenonesCross-Linking ReagentsGAL1 protein, S cerevisiaeGalactokinaseHerpes Simplex Virus Protein Vmw65PhenylalanineSaccharomyces cerevisiae ProteinsTATA-Box Binding ProteinTrans-Activatorscovalent chemical capturecross-linkingTATA-binding proteintranscription factorsunnatural amino acidVP16

Identifiers

PMID27213278
PMCPMC4972194
OpenAlexW2408659689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.