ArticleJournal of diabetes research2016
Increased Mortality in Diabetic Foot Ulcer Patients: The Significance of Ulcer Type.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- Diabetic foot ulcer is associated with cardiovascular-related mortality and morbidity - a systematic review and meta-analysis of 8062 patients.Endocrine · 2024Pooled it
- Influencing factors for the recurrence of diabetic foot ulcers: A meta-analysis.International wound journal · 2023Pooled it
- Does exercise improve healing of diabetic foot ulcers? A systematic review.Journal of foot and ankle research · 2021Pooled it
- Complementary Gene Therapy after Revascularization with the Saphenous Vein in Diabetic Foot Syndrome.Genes · 2023Trial
- Translational development of ABCB5Stem cell research & therapy · 2022Trial
- Reliability of a novel thermal imaging system for temperature assessment of healthy feet.Journal of foot and ankle research · 2018Trial
- A qualitative study exploring and understanding the experiences and unmet needs of adults with type 2 diabetes and diabetes-related foot ulcers.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- The burden of diabetic foot ulcers in a multi-ethnic Asian cohort.Diabetic medicine : a journal of the British Diabetic Association · 2026Observational
- A Retrospective Study of Infections and Antibiotic Susceptibility in Diabetic Foot Ulcers.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Article
- Physiotherapy Intervention for Diabetic Foot Ulcers: A Scoping Review.Diseases (Basel, Switzerland) · 2026Review
- Microfluidics, 3D bioprinted scaffold and organ-on-chip with biosensing activated therapeutic strategies for diabetic wound healing.Frontiers in bioengineering and biotechnology · 2026Review
- Nationwide study of income-based disparities in diabetic limb preservation in South Korea.Scientific reports · 2025Article
- Home-Based Exercise to Improve Functional Outcomes in Veterans With a Recently Healed Diabetic Foot Ulcer: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2025Article
- The use of SGLT2 inhibitors in people with diabetes-related foot disease: A Delphi-based consensus study.Diabetes, obesity & metabolism · 2025Article
- A Comparison of All-Cause Mortality in Patients Who Required Glaucoma Surgery for Neovascular Glaucoma or Primary Open-Angle Glaucoma: A Retrospective Cohort Study.Vision (Basel, Switzerland) · 2025Article
- A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi-centre randomised control trial (MiFoot study).Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Gaussian random fields as an abstract representation of patient metadata for multimodal medical image segmentation.Scientific reports · 2025Article
- Increased risk of major adverse cardiovascular events in patients with deep and infected diabetes-related foot ulcers.Diabetologia · 2025Article
- The relationship between at-risk foot and all-cause and cardiovascular mortality among the population with diabetes.Frontiers in medicine · 2025Article
- Correlation study on the risk of cardiovascular adverse events in diabetic foot patients based on machine learning - a retrospective cohort study.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic foot ulcer (DFU) patients have a greater than twofold increase in mortality compared with nonulcerated diabetic patients. We investigated (a) cause of death in DFU patients, (b) age at death, and (c) relationship between cause of death and ulcer type. This was an eleven-year retrospective study on DFU patients who attended King's College Hospital Foot Clinic and subsequently died. A control group of nonulcerated diabetic patients was matched for age and type of diabetes mellitus. The cause of death was identified from death certificates (DC) and postmortem (PM) examinations. There were 243 DFU patient deaths during this period. Ischaemic heart disease (IHD) was the major cause of death in 62.5% on PM compared to 45.7% on DC. Mean age at death from IHD on PM was 5 years lower in DFU patients compared to controls (68.2 ± 8.7 years versus 73.1 ± 8.0 years, P = 0.015). IHD as a cause of death at PM was significantly linked to neuropathic foot ulcers (OR 3.064, 95% CI 1.003-9.366, and P = 0.049). Conclusions. IHD is the major cause of premature mortality in DFU patients with the neuropathic foot ulcer patients being at a greater risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.