ArticleBioMed research international2016
Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The Predictive Value of Melatonin Levels for the Development of Diabetic Nephropathy in Men with Type 2 Diabetes Mellitus.Reports of biochemistry & molecular biology · 2024Article
- Review
- Betatrophin and Insulin Resistance.Metabolites · 2022Review
- ANGPTL8 in metabolic homeostasis: more friend than foe?Open biology · 2021Review
- ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways.Molecular biology reports · 2021Review
- Effects of vitamin D on apoptosis and betatrophin in the kidney tissue of experimental diabetic rats.Acta bio-medica : Atenei Parmensis · 2020Article
- Thyroid Nodules in Type 2 Diabetes Mellitus.Current medical science · 2019Article
- Decreased circulating levels of ANGPTL8 in Graves' disease patients.Hormones (Athens, Greece) · 2019Article
- Observational
- Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism.BioMed research international · 2019Article
- Observational
- Thyroid Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy: A Single Center Study.Journal of thyroid research · 2018Article
- Article
- The correlation between serum free thyroxine and regression of dyslipidemia in adult males: A 4.5-year prospective study.Medicine · 2017Observational
- Cloning, expression, and spectral analysis of mouse betatrophin.Medical journal of the Islamic Republic of Iran · 2017Article
- Serum fibroblast growth factor 19 is decreased in patients with overt hypothyroidism and subclinical hypothyroidism.Medicine · 2016Observational
- The Effects of Serum ANGPTL8/betatrophin on the Risk of Developing the Metabolic Syndrome - A Prospective Study.Scientific reports · 2016Article
- Alterations in serum concentrations of visfatin and betatrophin in dogs with hypothyroidism.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone (TH) affects many metabolic processes such as promoting oxidation of sugar, fat, and protein in many tissues. Thyroid dysfunction is associated with metabolic disorders. The newly discovered adipocyte- and hepatocyte-derived cytokine, betatrophin, has been reported to be involved in metabolic diseases, but its influence on thyroid dysfunction is uncertain. Therefore, the present study aims to evaluate circulating betatrophin levels in subjects with different thyroid function status and to predict the factors associated with betatrophin levels, especially whether thyroid stimulating hormone (TSH), TH, or thyroid autoantibodies are associated with betatrophin levels. In the study, serum betatrophin was measured in the subjects grouped as overt hypothyroidism (OH), subclinical hypothyroidism (SCH), euthyroid with isolated thyroid peroxidase antibody positivity (isolated Ab), and healthy control (HC), according to their thyroid functions. From our results, we found that betatrophin may be associated with thyroid insufficiency but not thyroid autoimmunity. Thus, when interpreting the results of betatrophin, thyroid functions should also be taken into consideration.
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