ArticleSurgical neurology international2016
Post-traumatic anosmia in patients with mild traumatic brain injury (mTBI): A systematic and illustrated review.
Article in Surgical neurology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Olfactory Dysfunction Following Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neuropsychology review · 2023Pooled it
- Neural Changes in Patients with Post-Traumatic Anosmia: Insights from Resting-State fMRI.Journal of biomedical physics & engineering · 2026Article
- A Prefrontal Neuromodulation Route for Post-Traumatic Olfactory Dysfunction: A Perspective Supported by Recovery During Left-DLPFC rTMS.Brain sciences · 2026Article
- Sudden sensorineural olfactory loss: a structured narrative review and proposal for a standardised terminological framework.Frontiers in surgery · 2026Review
- Article
- Olfactory dysfunction with traumatic brain injury and posttraumatic-stress symptoms in post-deployed military personnel.Frontiers in neurology · 2025Article
- Spatiotemporal regulation by downstream genes ofFrontiers in cell and developmental biology · 2025Article
- Traumatic brain injury-induced inflammatory changes in the olfactory bulb disrupt neuronal networks leading to olfactory dysfunction.Brain, behavior, and immunity · 2023Article
- Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study.Environmental health perspectives · 2023Article
- Brain Trauma and the Secondary Cascade in Humans: Review of the Potential Role of Vitamins in Reparative Processes and Functional Outcome.Behavioral sciences (Basel, Switzerland) · 2023Review
- A study of depression, partnership and sexual satisfaction in patients with post-traumatic olfactory disorders.Scientific reports · 2021Article
- Multi-Modal Analysis of Resting-State fMRI Data in mTBI Patients and Association With Neuropsychological Outcomes.Frontiers in neurology · 2021Article
- MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury.Brain research · 2020Article
- Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis.Current allergy and asthma reports · 2020Review
- A semi-quantitative sport-specific assessment of recurrent traumatic brain injury: the TraQ questionnaire and its application in American football.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions.Molecular neurobiology · 2019Article
- Olfactory discrimination in disorders of consciousness: A new sniff protocol.Brain and behavior · 2019Article
- Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury.Frontiers in cellular neuroscience · 2019Article
- Impaired brain response to odors in patients with varied severity of olfactory loss after traumatic brain injury.Journal of neurology · 2018Article
- Post-traumatic taste disorders: a case series.Journal of neurology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlfactory dysfunction (OD) is a disorder associated with traumatic brain injury (TBI), which is prevalent in up to 20% of patients suffering from TBI. Nevertheless, most studies focusing on the relationship between OD and TBIs do not differentiate between the different types of TBI (mild, medium, and severe). In this paper, we conducted a comprehensive and systematic review of the existing literature for the association between mild TBI (mTBI) and OD in order to examine their relationship, focusing on its neurosurgical management and the radiographic characteristics.
methodsThe MEDLINE database was systematically reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. We found 66 articles, of which 10 fulfilled our criteria.
resultsAll except two studies reported a significant association between trauma severity and olfaction. Two studies found a negative correlation between TBI severity and olfactory bulb volume with one reporting an r value of -0.62). Three studies reported an association between the observation of radiographic intracranial hemorrhage or skull base fractures and the history of TBI.
conclusionAccording to our search results, we conclude that OD is a prevalent but underdiagnosed problem in mTBI. Because OD is associated with a significant decrease in quality of life, we think that neurosurgical teams need to asses olfactory function in mTBI patients when they report to clinics. To illustrate this scenario, we include two distinct cases of patients with anosmia after mTBI in this review. Finally, we suggest a treatment algorithm for patients with mTBI so that a possible OD can be diagnosed and treated as early as possible.
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