ReviewJournal of therapeutic ultrasound2016
Acoustic neuromodulation from a basic science prospective.
Review in Journal of therapeutic ultrasound, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- A Comprehensive Review of Low-Intensity Focused Ultrasound Parameters and Applications in Neurologic and Psychiatric Disorders.Neuromodulation : journal of the International Neuromodulation Society · 2025Review
- Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability.bioRxiv : the preprint server for biology · 2023Article
- Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application.Frontiers in neurology · 2023Review
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation.Frontiers in human neuroscience · 2022Review
- Mechanisms and Applications of Neuromodulation Using Surface Acoustic Waves-A Mini-Review.Frontiers in neuroscience · 2021Review
- Focused Ultrasound (FUS) for Chronic Pain Management: Approved and Potential Applications.Neurology research international · 2021Review
- Spherical Array System for High-Precision Transcranial Ultrasound Stimulation and Optoacoustic Imaging in Rodents.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans.Frontiers in human neuroscience · 2020Article
- Iterative Curve Fitting of the Bioheat Transfer Equation for Thermocouple-Based Temperature Estimation In Vitro and In Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Optimizing Computer-Brain Interface Parameters for Non-invasive Brain-to-Brain Interface.Frontiers in neuroinformatics · 2020Article
- Ultrasonic Neuromodulation and Sonogenetics: A New Era for Neural Modulation.Frontiers in physiology · 2020Review
- A causal study of the phenomenon of ultrasound neurostimulation applied to an in vivo invertebrate nervous model.Scientific reports · 2019Article
- Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons.BMC neuroscience · 2019Article
- Modulation of Brain Function and Behavior by Focused Ultrasound.Current behavioral neuroscience reports · 2018Article
- Activation of Piezo1 but Not NaUltrasound in medicine & biology · 2018Article
- Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Increased Excitability Induced in the Primary Motor Cortex by Transcranial Ultrasound Stimulation.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We present here biophysical models to gain deeper insights into how an acoustic stimulus might influence or modulate neuronal activity. There is clear evidence that neural activity is not only associated with electrical and chemical changes but that an electro-mechanical coupling is also involved. Currently, there is no theory that unifies the electrical, chemical, and mechanical aspects of neuronal activity. Here, we discuss biophysical models and hypotheses that can explain some of the mechanical aspects associated with neuronal activity: the soliton model, the neuronal intramembrane cavitation excitation model, and the flexoelectricity hypothesis. We analyze these models and discuss their implications on stimulation and modulation of neuronal activity by ultrasound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.