ArticleJournal of bioanalysis & biomedicine2015
Systemic Transcriptional Alterations of Innate and Adaptive Immune Signaling Pathways in Atherosclerosis, Ischemia Stroke, and Myocardial Infarction.
Article in Journal of bioanalysis & biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Adipocytokine Pathway Dysregulation Characterizes Immune-Related Molecular Subtypes and Candidate Biomarkers in Myocardial Infarction.Journal of inflammation research · 2026Article
- Article
- The relationship of redox signaling with the risk for atherosclerosis.Frontiers in pharmacology · 2024Review
- Metagenomic sequencing of human cardiac tissue reveals Microbial RNA which correlates with Toll-like receptor-associated inflammation in patients with heart disease.Scientific reports · 2023Article
- Minor Changes for a Major Impact: A Review of Epigenetic Modifications in Cell-Based Therapies for Stroke.International journal of molecular sciences · 2022Review
- Changes to Urinary Proteome in High-Fat-DietBiomolecules · 2022Article
- Identification of key gene modules and pathways of human platelet transcriptome in acute myocardial infarction patients through co-expression network.American journal of translational research · 2021Article
- Crucial Gene Identification in Carotid Atherosclerosis Based on Peripheral Blood Mononuclear Cell (PBMC) Data by Weighted (Gene) Correlation Network Analysis (WGCNA).Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Epigenetic regulation of inflammation in stroke.Therapeutic advances in neurological disorders · 2018Review
- Sex differences in stroke across the lifespan: The role of T lymphocytes.Neurochemistry international · 2017Review
- Nanomedicine applied to cardiovascular diseases: latest developments.Therapeutic advances in cardiovascular disease · 2017Review
- Sex differences in neuroinflammation and neuroprotection in ischemic stroke.Journal of neuroscience research · 2017Review
- Analysis of gene expression profile identifies potential biomarkers for atherosclerosis.Molecular medicine reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundTranscriptional profiles are available for a variety of cardiovascular-related diseases. The goal of this study was to compare blood transcriptional profiles of the Toll-like receptor (TLR), T-cell receptor (TCR), and B-cell receptor (BCR) signaling pathways in asymptomatic atherosclerosis, acute ischemic stroke, and myocardial infarction patients to identify common mechanisms of immune regulation and their association with epigenetic regulation. METHODS AND
resultsPeripheral blood gene expression profiles from human atherosclerosis-related diseases and healthy controls were downloaded from Gene Expression Omnibus (GEO). Genes in the TLR, TCR, and BCR pathways were retrieved from the NCBI BioSystems database. Significance of gene enrichment and concordance of expression changes in each pathway was compared between studies. Gene expression was significantly correlated across the three disease conditions (p<10
conclusionCommon biologically relevant networks associated with immune regulation in stroke, atherosclerosis, and myocardial infarction were discovered. Given the high correlation of DNMT1 with these immune signaling pathways, epigenetic regulation may contribute to the coordination of innate and adaptive immune response in all CVD disease states. Down-regulation of the TCR-BCR axis in the adaptive immune system offers critical information for the investigation of the functional mechanisms underlying chronic inflammation-induced immune suppression in cardiovascular disease and stroke.
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