Evidence map›Paper›PMID 27212922›Full record

ArticleNeural regeneration research2016

Moxibustion upregulates hippocampal progranulin expression.

Tao Yi, Li Qi, Ji Li, Jing-Jing Le, Lei Shao, Xin Du, Jing-Cheng Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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  16. Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis.Evidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tao YiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.
Li QiE-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ji LiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.
Jing-Jing LeDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.
Lei ShaoDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.
Xin DuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.
Jing-Cheng DongDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.ORCID 0000-0002-3645-0324
Fudan University · CNHuashan Hospital · CNShanghai Municipal Education Commission · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In China, moxibustion is reported to be useful and has few side effects for chronic fatigue syndrome, but its mechanisms are largely unknown. More recently, the focus has been on the wealth of information supporting stress as a factor in chronic fatigue syndrome, and largely concerns dysregulation in the stress-related hypothalamic-pituitary-adrenal axis. In the present study, we aimed to determine the effect of moxibustion on behavioral symptoms in chronic fatigue syndrome rats and examine possible mechanisms. Rats were subjected to a combination of chronic restraint stress and forced swimming to induce chronic fatigue syndrome. The acupoints Guanyuan (CV4) and Zusanli (ST36, bilateral) were simultaneously administered moxibustion. Untreated chronic fatigue syndrome rats and normal rats were used as controls. Results from the forced swimming test, open field test, tail suspension test, real-time PCR, enzyme-linked immunosorbent assay, and western blot assay showed that moxibustion treatment decreased mRNA expression of corticotropin-releasing hormone in the hypothalamus, and adrenocorticotropic hormone and corticosterone levels in plasma, and markedly increased progranulin mRNA and protein expression in the hippocampus. These findings suggest that moxibustion may relieve the behavioral symptoms of chronic fatigue syndrome, at least in part, by modulating the hypothalamic-pituitary-adrenal axis and upregulating hippocampal progranulin.

Indexed as

adrenocorticotropic hormonebehavioral symptomschronic fatigue syndromecorticosteronecorticotrophin-releasing hormonehippocampushypothalamic-pituitary-adrenal axismoxibustionnerve regenerationneural regenerationprogranulintraditional Chinese medicine

Identifiers

PMID27212922
PMCPMC4870918
OpenAlexW2337297255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.