ArticleAnnals of pediatric cardiology
Procalcitonin as a biomarker of bacterial infection in pediatric patients after congenital heart surgery.
Article in Annals of pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Trial
- Clinical study of serum procalcitonin level in patients with myocardial infarction complicated by pulmonary infection.Experimental and therapeutic medicine · 2018Article
- Is Procalcitonin Useful in Pediatric Critical Care Patients?Biomarker insights · 2018Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial infection (BI) after congenital heart surgery (CHS) is associated with increased morbidity and is difficult to differentiate from systemic inflammatory response syndrome caused by cardiopulmonary bypass (CPB). Procalcitonin (PCT) has emerged as a reliable biomarker of BI in various populations.
aimTo determine the optimal PCT threshold to identify BI among children suspected of having infection following CPB. SETTING AND
designSingle-center retrospective observational study. MATERIALS AND
methodsMedical records of all the patients admitted between January 2013 and April 2015 were reviewed. Patients in the age range of 0-21 years of age who underwent CHS requiring CPB in whom PCT was drawn between postoperative days 0-8 due to suspicion of infection were included. STATISTICAL ANALYSIS: The Wilcoxon rank-sum test was used for nonparametric variables. The diagnostic performance of PCT was evaluated using a receiver operating characteristic (ROC) curve.
resultsNinety-eight patients were included. The median age was 2 months (25th and 75th interquartile of 0.1-7.5 months). Eleven patients were included in the BI group. The median PCT for the BI group (3.42 ng/mL, 25th and 75th interquartile of 2.34-5.67) was significantly higher than the median PCT for the noninfected group (0.8 ng/mL, 25th and 75th interquartile 0.38-3.39), P = 0.028. The PCT level that yielded the best compromise between the sensitivity (81.8%) and specificity (66.7%) was 2 ng/mL with an area under the ROC curve of 0.742.
conclusionA PCT less than 2 ng/mL makes BI unlikely in children suspected of infection after CHS.
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