Evidence map›Paper›PMID 27212809›Full record

Trial reportMediators of inflammation2016

Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study.

Felix Kaspar, Herbert F Jelinek, Steven Perkins, Hayder A Al-Aubaidy, Bev deJong, Eugene Butkowski

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Mediators of inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  5. Trial
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  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Endocrine responses of the stress system to different types of exercise.Reviews in endocrine & metabolic disorders · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Felix KasparDepartment of Biotechnology, Institute for Biochemistry and Biotechnology, Technical University Braunschweig, 38126 Braunschweig, Germany; School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
Herbert F JelinekSchool of Community Health, Charles Sturt University, Albury, NSW 2640, Australia; Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia.
Steven PerkinsSchool of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
Hayder A Al-AubaidySchool of Medicine, University of Tasmania, Hobart, TAS 7001, Australia.
Bev deJongSchool of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
Eugene ButkowskiSchool of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
Charles Sturt University · AUTechnische Universität Braunschweig · DEUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study compared acute and late effect of single-bout endurance training (ET) and high-intensity interval training (HIIT) on the plasma levels of four inflammatory cytokines and C-reactive protein and insulin-like growth factor 1.

designCohort study with repeated-measures design.

methodsSeven healthy untrained volunteers completed a single bout of ET and HIIT on a cycle ergometer. ET and HIIT sessions were held in random order and at least 7 days apart. Blood was drawn before the interventions and 30 min and 2 days after the training sessions. Plasma samples were analyzed with ELISA for the interleukins (IL), IL-1β, IL-6, and IL-10, monocyte chemoattractant protein-1 (MCP-1), insulin growth factor 1 (IGF-1), and C-reactive protein (CRP). Statistical analysis was with Wilcoxon signed-rank tests.

resultsET led to both a significant acute and long-term inflammatory response with a significant decrease at 30 minutes after exercise in the IL-6/IL-10 ratio (-20%; p = 0.047) and a decrease of MCP-1 (-17.9%; p = 0.03).

conclusionThis study demonstrates that ET affects the inflammatory response more adversely at 30 minutes after exercise compared to HIIT. However, this is compensated by a significant decrease in MCP-1 at two days associated with a reduced risk of atherosclerosis.

Indexed as

Acute-Phase ReactionAdultC-Reactive ProteinExerciseFemaleHigh-Intensity Interval TrainingHumansInflammationInterleukin-10Interleukin-6MaleYoung AdultC-Reactive ProteinInterleukin-10Interleukin-6

Identifiers

PMID27212809
PMCPMC4861798
OpenAlexW2345264576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.