Evidence map›Paper›PMID 27212739›Full record

ArticleJournal of the American Statistical Association2016

Stepwise Signal Extraction via Marginal Likelihood.

Chao Du, Chu-Lan Michael Kao, S C Kou

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Testing for dependence on tree structures.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Statistics and Related Topics in Single-Molecule Biophysics.Annual review of statistics and its application · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chao DuStatistics, University of Virginia, Charlottesville, VA 22904 ( cd2wb@virginia.edu ).
Chu-Lan Michael KaoResearch Center of Adaptive Data Analysis, National Central University, Taoyuan County 32001, Taiwan ( chulankao@gmail.com ).
S C KouStatistics, Harvard University, Cambridge, MA, 02138 ( kou@stat.harvard.edu ).

Funding

Statistical Models and Inference in the Single-Molecule Approach to BiologyR01GM090202 · NIGMS · HARVARD UNIVERSITY · PI KOU, SAMUEL · 2009 to 2012
$1.2M
NIGMS NIH HHS R01 GM090202
6 · The paper itself

Abstract

This paper studies the estimation of stepwise signal. To determine the number and locations of change-points of the stepwise signal, we formulate a maximum marginal likelihood estimator, which can be computed with a quadratic cost using dynamic programming. We carry out extensive investigation on the choice of the prior distribution and study the asymptotic properties of the maximum marginal likelihood estimator. We propose to treat each possible set of change-points equally and adopt an empirical Bayes approach to specify the prior distribution of segment parameters. Detailed simulation study is performed to compare the effectiveness of this method with other existing methods. We demonstrate our method on single-molecule enzyme reaction data and on DNA array CGH data. Our study shows that this method is applicable to a wide range of models and offers appealing results in practice.

Indexed as

array CGHasymptotic consistencychange-pointschoice of priordynamic programmingmarginal likelihoodmodel selectionsingle-molecule experiments

Identifiers

PMID27212739
PMCPMC4874345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.