Evidence map›Paper›PMID 27212253›Full record

ReviewSeminars in cell & developmental biology2017

Epithelial cell extrusion: Pathways and pathologies.

Swapna Aravind Gudipaty, Jody Rosenblatt

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Evidence for Drop-Like Nuclear Deformation in Sheared Endothelial Monolayers.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Cell extrusion drives neural crest cell delamination.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. VopX, a novelmBio · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Swapna Aravind GudipatyDepartment of Oncological Sciences, Huntsman Cancer Institute, University Of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA.
Jody RosenblattDepartment of Oncological Sciences, Huntsman Cancer Institute, University Of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA. Electronic address: Jody.Rosenblatt@hci.utah.edu.
Huntsman Cancer Institute · US

Funding

The Role of Extrusion in Controlling Epithelial HomeostasisR01GM102169 · NIGMS · UNIVERSITY OF UTAH · PI BECKERLE, MARY C., ROSENBLATT, JODY SNOW · 2012 to 2019
$3.4M
NIGMS NIH HHS R01 GM102169
6 · The paper itself

Abstract

To remove dying or unwanted cells from an epithelium while preserving the barrier function of the layer, epithelia use a unique process called cell extrusion. To extrude, the cell fated to die emits the lipid Sphingosine 1 Phosphate (S1P), which binds the G-protein-coupled receptor Sphingosine 1 Phosphate receptor 2 (S1P

Indexed as

Signal TransductionAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAnimalsApoptosisCell MovementDNA-Binding ProteinsEpithelial CellsGene Expression RegulationHumansListeria monocytogenesLysophospholipidsNeuronal Apoptosis-Inhibitory ProteinProto-Oncogene Proteins p21(ras)Receptors, LysosphingolipidSalmonella typhimuriumAdenomatous Polyposis Coli ProteinAPC protein, humanDNA-Binding ProteinsKRAS protein, humanLysophospholipidsNAIP protein, humanNeuronal Apoptosis-Inhibitory ProteinProto-Oncogene Proteins p21(ras)Receptors, LysosphingolipidS1PR2 protein, humanSLC2A4RG protein, humanSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsTranscription FactorsEpithelial extrusionMicrotubulesPiezo1RhoSphingosine-1-phosphateSphingosine-1-phosphate receptor 2

Identifiers

PMID27212253
PMCPMC5116298
OpenAlexW2407099092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.