Evidence map›Paper›PMID 27212140›Full record

Trial reportNature communications2016

A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring.

Somayeh Imani, Amay J Bandodkar, A M Vinu Mohan, Rajan Kumar, Shengfei Yu, Joseph Wang, Patrick P Mercier

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed
46.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 832 citations in OpenAlex.

  1. Trial
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  10. Nanomaterial-Based Inkjet Printing for Electrochemical Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
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  18. Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025
    Article
  19. Article
  20. Review

135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Somayeh ImaniDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0407, USA.
Amay J BandodkarDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093-0448, USA.
A M Vinu MohanDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093-0448, USA.
Rajan KumarDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093-0448, USA.
Shengfei YuDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0407, USA.
Joseph WangDepartment of Nanoengineering, University of California, San Diego, La Jolla, California 92093-0448, USA.
Patrick P MercierDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0407, USA.
University of California, San Diego · US

Funding

A Flexible Epidermal Multimodal Health MonitorR21EB019698 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MERCIER, PATRICK P · 2015 to 2016
$395k
NIBIB NIH HHS R21 EB019698
6 · The paper itself

Abstract

Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a small number of physical or electrophysiological parameters, and neglect the rich chemical information available from biomarkers. Here, we introduce a skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram), for more comprehensive fitness monitoring than from physical or electrophysiological sensors alone. The two sensing modalities, comprising a three-electrode amperometric lactate biosensor and a bipolar electrocardiogram sensor, are co-fabricated on a flexible substrate and mounted on the skin. Human experiments reveal that physiochemistry and electrophysiology can be measured simultaneously with negligible cross-talk, enabling a new class of hybrid sensing devices.

Indexed as

ElectrocardiographyBiomarkersBiosensing TechniquesExercise TestHumansLactic AcidMaleMonitoring, PhysiologicSweatBiomarkersLactic Acid

Identifiers

PMID27212140
PMCPMC4879240
OpenAlexW2401823338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.