Evidence map›Paper›PMID 27212028›Full record

Trial reportJACC. Cardiovascular interventions2016

6-Month Versus 12-Month Dual-Antiplatelet Therapy Following Long Everolimus-Eluting Stent Implantation: The IVUS-XPL Randomized Clinical Trial.

Sung-Jin Hong, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Ae-Young Her, Yong Hoon Kim, Yangsoo Jang, Myeong-Ki Hong and 1 more

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in JACC. Cardiovascular interventions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01308281 (Impact of IntraVascular UltraSound Guidance on Outcomes of Xience Prime Stents in Long Lesions), which is not on this map. Cited by 63 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 23 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01308281 nacompletednot on this map

Impact of IntraVascular UltraSound Guidance on Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study)

TypeinterventionalSponsorYonsei UniversityRan2010 to 2015Enrolled1,079ConditionsCoronary Artery DiseaseArmsPCI with IVUS guidance, PCI without IVUS guidance
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 23 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Abbreviated versus Standard Duration of DAPT after PCI: A Systematic Review and Network Meta-analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Pooled it

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sung-Jin HongDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University, Seoul, South Korea; Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
Dong-Ho ShinDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
Jung-Sun KimDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
Byeong-Keuk KimDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
Young-Guk KoDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
Donghoon ChoiDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
Ae-Young HerSchool of Medicine, Kangwon National University, Chuncheon, Korea.
Yong Hoon KimSchool of Medicine, Kangwon National University, Chuncheon, Korea.
Yangsoo JangDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
Myeong-Ki HongDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: mkhong61@yuhs.ac.
IVUS-XPL Investigators
Yonsei University Health System · KRKangwon National University · KRYonsei University · KRInje University Sanggye Paik Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate whether a 6-month dual-antiplatelet therapy (DAPT) duration was comparable with a 12-month duration in patients who underwent everolimus-eluting stent implantation.

backgroundWell-designed studies that determine optimal DAPT strategies after everolimus-eluting stent implantation are limited.

methodsA total of 1,400 patients (implanted mean total stent length >45 mm) were randomly assigned to receive 6-month (n = 699) or 12-month (n = 701) DAPT between October 2010 and July 2014 at 20 centers in Korea. The primary endpoint was the composite of cardiac death, myocardial infarction, stroke, or TIMI (Thrombolysis in Myocardial Infarction) major bleeding at 1 year, analyzed using an intention-to-treat approach.

resultsThe primary endpoint occurred in 15 patients (2.2%) in the 6-month DAPT group and 14 patients (2.1%) in the 12-month DAPT group (hazard ratio [HR]: 1.07; p = 0.854). Definite or probable stent thrombosis occurred in 2 patients (0.3%) in the 6-month DAPT group and in 2 patients (0.3%) in the 12-month DAPT group (HR: 1.00; p = 0.999). There were no significant between-group differences in the primary endpoint in 686 patients with acute coronary syndrome (2.4% in both groups; HR: 1.00; p = 0.994) and in 506 patients with diabetes mellitus (2.2% [6-month] vs. 3.3% [12-month]; HR: 0.64; p = 0.428).

conclusionsCompared with 12-month DAPT, 6-month DAPT did not increase the composite events of cardiac death, myocardial infarction, stroke, or TIMI major bleeding at 1 year in patients who underwent everolimus-eluting stent implantation. (Impact of Intravascular Ultrasound Guidance on Outcomes of XIENCE PRIME Stents in Long Lesions [IVUS-XPL Study]; NCT01308281).

Indexed as

Drug-Eluting StentsAspirinCardiovascular AgentsClopidogrelCoronary ThrombosisDrug Administration ScheduleDrug Therapy, CombinationEverolimusHemorrhageHumansIntention to Treat AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsProsthesis DesignRepublic of KoreaAspirinCardiovascular AgentsClopidogrelEverolimusPlatelet Aggregation InhibitorsTiclopidinecoronary artery diseasedrug-eluting stent(s)dual-antiplatelet therapy

Identifiers

PMID27212028
OpenAlexW2396902189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.