ArticleCell systems2016
A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism.
Article in Cell systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Resolving tissue and cellular functions of parasitic nematodes.Trends in parasitology · 2025Review
- A genome-scale metabolic model of parasitic whipworm.Nature communications · 2023Article
- An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics.Frontiers in molecular biosciences · 2022Article
- Quo VadisMetabolites · 2021Review
- Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation.Disease models & mechanisms · 2021Article
- Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis.Metabolites · 2021Review
- Article
- Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.Ageing research reviews · 2020Review
- Modeling tissue-relevant Caenorhabditis elegans metabolism at network, pathway, reaction, and metabolite levels.Molecular systems biology · 2020Article
- Suggestions for Standardized Identifiers for Fatty Acyl Compounds in Genome Scale Metabolic Models and Their Application to the WormJamMetabolites · 2020Article
- Current status and applications of genome-scale metabolic models.Genome biology · 2019Review
- The Inducible Response of the NematodeFrontiers in microbiology · 2019Article
- Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift DuringFrontiers in molecular biosciences · 2019Article
- IsGenes & nutrition · 2019Article
- Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.Endocrine reviews · 2018Review
- Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model OrganismFrontiers in molecular biosciences · 2018Article
- Lipid and Carbohydrate Metabolism inGenetics · 2017Review
- Non-enzymatic molecular damage as a prototypic driver of aging.The Journal of biological chemistry · 2017Review
- Metabolic network modeling with model organisms.Current opinion in chemical biology · 2017Review
- The genome of Onchocerca volvulus, agent of river blindness.Nature microbiology · 2016Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a genome-scale model of Caenorhabditis elegans metabolism along with the public database ElegCyc (http://elegcyc.bioinf.uni-jena.de:1100), which represents a reference for metabolic pathways in the worm and allows for the visualization as well as analysis of omics datasets. Our model reflects the metabolic peculiarities of C. elegans that make it distinct from other higher eukaryotes and mammals, including mice and humans. We experimentally verify one of these peculiarities by showing that the lifespan-extending effect of L-tryptophan supplementation is dose dependent (hormetic). Finally, we show the utility of our model for analyzing omics datasets through predicting changes in amino acid concentrations after genetic perturbations and analyzing metabolic changes during normal aging as well as during two distinct, reactive oxygen species (ROS)-related lifespan-extending treatments. Our analyses reveal a notable similarity in metabolic adaptation between distinct lifespan-extending interventions and point to key pathways affecting lifespan in nematodes.
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