ArticleScientific reports2016
Dynamic finite-element model for efficient modelling of electric currents in electroporated tissue.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments.Frontiers in bioengineering and biotechnology · 2022Review
- Article
- Dynamic Electroporation Model Evaluation on Rabbit Tissues.Annals of biomedical engineering · 2021Article
- OpenEP: an open-source simulator for electroporation-based tumor treatments.Scientific reports · 2021Article
- HyCHEED System for Maintaining Stable Temperature Control during Preclinical Irreversible Electroporation Experiments at Clinically Relevant Temperature and Pulse Settings.Sensors (Basel, Switzerland) · 2020Article
- Electrochemotherapy Using Doxorubicin and Nanosecond Electric Field Pulses: A Pilot in Vivo Study.Molecules (Basel, Switzerland) · 2020Article
- Development of a Multi-Pulse Conductivity Model for Liver Tissue Treated With Pulsed Electric Fields.Frontiers in bioengineering and biotechnology · 2020Article
- A Review on Electroporation-Based Intracellular Delivery.Molecules (Basel, Switzerland) · 2018Review
- Non-invasive nanosecond electroporation for biocontrol of surface infections: an in vivo study.Scientific reports · 2018Article
- Membrane Permeabilization of Pathogenic Yeast in Alternating Sub-microsecond Electromagnetic Fields in Combination with Conventional Electroporation.The Journal of membrane biology · 2018Article
- Time-Dependent Finite Element Analysis of In Vivo Electrochemotherapy Treatment.Technology in cancer research & treatment · 2018Article
- Technological and Theoretical Aspects for Testing Electroporation on Liposomes.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In silico experiments (numerical simulations) are a valuable tool for non-invasive research of the influences of tissue properties, electrode placement and electric pulse delivery scenarios in the process of electroporation. The work described in this article was aimed at introducing time dependent effects into a finite element model developed specifically for electroporation. Reference measurements were made ex vivo on beef liver samples and experimental data were used both as an initial condition for simulation (applied pulse voltage) and as a reference value for numerical model calibration (measured pulse current). The developed numerical model is able to predict the time evolution of an electric pulse current within a 5% error over a broad range of applied pulse voltages, pulse durations and pulse repetition frequencies. Given the good agreement of the current flowing between the electrodes, we are confident that the results of our numerical model can be used both for detailed in silico research of electroporation mechanisms (giving researchers insight into time domain effects) and better treatment planning algorithms, which predict the outcome of treatment based on both spatial and temporal distributions of applied electric pulses.
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