Evidence map›Paper›PMID 27211567›Full record

ArticleEBioMedicine2016

Child Stunting is Associated with Low Circulating Essential Amino Acids.

Richard D Semba, Michelle Shardell, Fayrouz A Sakr Ashour, Ruin Moaddel, Indi Trehan, Kenneth M Maleta, M Isabel Ordiz, Klaus Kraemer, Mohammed A Khadeer, Luigi Ferrucci and 1 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 156 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 1 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03801317 nacompletednot on this mapstarted 2018, after this paper: background citation

The Effect of Bovine Colostrum/ Egg Supplementation in Young Malawian Children

TypeinterventionalSponsorWashington University School of MedicineRan2018 to 2020Enrolled278ConditionsStunting, Environmental Enteric DysfunctionArmsBC/ egg, Control, multiple micronutrient
NCT06933862 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Channa Striata Extract on Intestinal Inflammation and Nutritional Status in Malnutritional Toddlers After Albendazole Therapy in South Bangka District

TypeinterventionalSponsorIndonesia UniversityRan2025 to 2026Enrolled122ConditionsMalnourished ChildrenArmsStriatin, Placebo
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 1 synthesis or guideline pooled it, 338 citations in OpenAlex.

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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Richard D SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rdsemba@jhmi.edu.
Michelle ShardellNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Fayrouz A Sakr AshourDepartment of Nutrition & Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, USA.
Ruin MoaddelNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Indi TrehanDepartment of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi.
Kenneth M MaletaSchool of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi.
M Isabel OrdizDepartment of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
Klaus KraemerSight and Life, Basel, Switzerland; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mohammed A KhadeerNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Mark J ManaryDepartment of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi.
National Institutes of Health · USUniversity of Malawi · MWJohns Hopkins University · USUniversity of Maryland, College Park · USWashington University in St. Louis · US

Funding

Disease Status Drug Metabolism and New Drug Discovery ZIAAG000297 · NIA · NATIONAL INSTITUTE ON AGING · PI EGAN, JOSEPHINE · 2009 to 2025
$38.2M
Oxidative stress and the pathogenesis of sarcopenia and disability in older womenR01AG027012 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2005 to 2018
$3.6M
Systemic complement and age-related macular degeneration.R01EY024596 · NEI · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2014 to 2016
$1.6M
NEI NIH HHS R01 EY024596NIA NIH HHS R01 AG027012
6 · The paper itself

Abstract

backgroundStunting affects about one-quarter of children under five worldwide. The pathogenesis of stunting is poorly understood. Nutritional interventions have had only modest effects in reducing stunting. We hypothesized that insufficiency in essential amino acids may be limiting the linear growth of children.

methodsWe used a targeted metabolomics approach to measure serum amino acids, glycerophospholipids, sphingolipids, and other metabolites using liquid chromatography-tandem mass spectrometry in 313 children, aged 12-59months, from rural Malawi. Children underwent anthropometry.

findingsSixty-two percent of the children were stunted. Children with stunting had lower serum concentrations of all nine essential amino acids (tryptophan, isoleucine, leucine, valine, methionine, threonine, histidine, phenylalanine, lysine) compared with nonstunted children (p<0.01). In addition, stunted children had significantly lower serum concentrations of conditionally essential amino acids (arginine, glycine, glutamine), non-essential amino acids (asparagine, glutamate, serine), and six different sphingolipids compared with nonstunted children. Stunting was also associated with alterations in serum glycerophospholipid concentrations.

interpretationOur findings support the idea that children with a high risk of stunting may not be receiving an adequate dietary intake of essential amino acids and choline, an essential nutrient for the synthesis of sphingolipids and glycerophospholipids.

Indexed as

Amino Acids, EssentialChild, PreschoolCholineChromatography, LiquidCross-Sectional StudiesFemaleGlycerophospholipidsGrowth DisordersHumansInfantMalawiMaleMetabolomicsRisk FactorsRural PopulationSphingolipidsAmino Acids, EssentialCholineGlycerophospholipidsSphingolipidsAmino acidsChildrenGlycerophospholipidsMalnutritionSphingolipidsStunting

Identifiers

PMID27211567
PMCPMC4856740
OpenAlexW2280457477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.