ArticleEBioMedicine2016
Creation of a Large Adipose Tissue Construct in Humans Using a Tissue-engineering Chamber: A Step Forward in the Clinical Application of Soft Tissue Engineering.
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05460780 (First-in-human Study of MATTISSE® Tissue Engineering Chamber in Adult Female After Total Mastectomy for Breast Cancer in Immediate or Delayed 2-stage Tissue Expander Reconstruction or Conversion From Implant-based to Autologous Reconstruction), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First-in-human Study of MATTISSE® Tissue Engineering Chamber in Adult Female After Total Mastectomy for Breast Cancer in Immediate or Delayed 2-stage Tissue Expander Reconstruction or Conversion From Implant-based to Autologous Reconstruction
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Breast Reconstruction with a Tissue Engineering and Regenerative Medicine Approach (Systematic Review).Annals of biomedical engineering · 2020Pooled it
- Scaffold-based breast conserving surgery in patients with non-malignant breast lesions: long-term follow-up of a first-in-human pilot study on the REGENERA™ biomimetic breast implant.Breast cancer (Tokyo, Japan) · 2026Trial
- Cell-free biomimetic polyurethane-based scaffold for breast reconstruction following non-malignant lesion resection. A first-in-human study.Breast cancer (Tokyo, Japan) · 2023Trial
- Vascularized Flaps as Living Bioreactors in Bone Tissue Engineering: From Biological Principles to Translational Strategies-A Narrative Review.Journal of functional biomaterials · 2026Review
- State of Research on Tissue Engineering with 3D Printing for Breast Reconstruction.Journal of clinical medicine · 2025Review
- Review
- 3D-printed CoSi/PCL composite scaffold with NIR-II photothermal ability and enhanced adipogenic activity for breast reconstruction after mastectomy.Materials today. Bio · 2025Article
- Advanced Hydrogels in Breast Cancer Therapy.Gels (Basel, Switzerland) · 2024Review
- Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model.Bioengineering (Basel, Switzerland) · 2024Article
- Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration.Tissue engineering and regenerative medicine · 2024Review
- Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions.Annals of translational medicine · 2024Review
- Methacrylated Gelatin as a Scaffold for Mechanically Isolated Stromal Vascular Fraction for Cutaneous Wound Repair.International journal of molecular sciences · 2023Article
- Clinical Applicability of Visible Light-Mediated Cross-linking for Structural Soft Tissue Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Convergence of scaffold-guided bone regeneration principles and microvascular tissue transfer surgery.Science advances · 2023Article
- Polydopamine-assisted tranilast immobilization on a PLA chamber to enhance fat flaps regeneration by reducing tissue fibrosis.RSC advances · 2023Article
- Preclinical Study of Radiation on Fat Flap Regeneration under Tissue-engineering Chamber: Potential Consequences for Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2022Article
- Techniques and Innovations in Flap Engineering: A Review.Plastic and reconstructive surgery. Global open · 2022Article
- Pre-Vascularized Electrospun Graphene Oxide-Gelatin Chamber for Intestinal Wall Defect Repair.International journal of nanomedicine · 2022Article
- Pliable, Scalable, and Degradable Scaffolds with Varying Spatial Stiffness and Tunable Compressive Modulus Produced by Adopting a Modular Design Strategy at the Macrolevel.ACS polymers Au · 2021Article
- 3D Printing in Breast Reconstruction: From Bench to Bed.Frontiers in surgery · 2021Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering is currently exploring new and exciting avenues for the repair of soft tissue and organ defects. Adipose tissue engineering using the tissue engineering chamber (TEC) model has yielded promising results in animals; however, to date, there have been no reports on the use of this device in humans. Five female post mastectomy patients ranging from 35 to 49years old were recruited and a pedicled thoracodorsal artery perforator fat flap ranging from 6 to 50ml was harvested, transposed onto the chest wall and covered by an acrylic perforated dome-shaped chamber ranging from 140 to 350cm(3). Magnetic resonance evaluation was performed at three and six months after chamber implantation. Chambers were removed at six months and samples were obtained for histological analysis. In one patient, newly formed tissue to a volume of 210ml was generated inside the chamber. One patient was unable to complete the trial and the other three failed to develop significant enlargement of the original fat flap, which, at the time of chamber explantation, was encased in a thick fibrous capsule. Our study provides evidence that generation of large well-vascularized tissue engineered constructs using the TEC is feasible in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.