ArticleNature communications2016
The fin-to-limb transition as the re-organization of a Turing pattern.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 104 citations in OpenAlex.
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- Development of whole-limb skeletal patterning through the coordination of growth and self-organization models.PLoS computational biology · 2026Article
- LimbNET: collaborative platform for simulating spatial patterns of gene networks in limb development.Molecular systems biology · 2026Article
- Evolutionary pathway and genetic mechanisms of fin-to-limb transition in vertebrates.Frontiers in cell and developmental biology · 2026Review
- BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death.Development, growth & differentiation · 2026Article
- Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development.Nature ecology & evolution · 2025Article
- The emergence ofFrontiers in cell and developmental biology · 2025Article
- Anterior-posterior constraint on Hedgehog signaling by hhip in teleost fin elaboration.Development (Cambridge, England) · 2024Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- A diffusible small-RNA-based Turing system dynamically coordinates organ polarity.Nature plants · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Fgf signalling is required for gill slit formation in the skate, Leucoraja erinacea.Developmental biology · 2024Article
- Protein-protein interaction network module changes associated with the vertebrate fin-to-limb transition.Scientific reports · 2023Article
- Development shapes the evolutionary diversification of rodent stripe patterns.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- Air-breathing behavior underlies the cell death in limbs of Rana pirica tadpoles.Zoological letters · 2023Article
- Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Article
- Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Turing mechanism implemented by BMP, SOX9 and WNT has been proposed to control mouse digit patterning. However, its generality and contribution to the morphological diversity of fins and limbs has not been explored. Here we provide evidence that the skeletal patterning of the catshark Scyliorhinus canicula pectoral fin is likely driven by a deeply conserved Bmp-Sox9-Wnt Turing network. In catshark fins, the distal nodular elements arise from a periodic spot pattern of Sox9 expression, in contrast to the stripe pattern in mouse digit patterning. However, our computer model shows that the Bmp-Sox9-Wnt network with altered spatial modulation can explain the Sox9 expression in catshark fins. Finally, experimental perturbation of Bmp or Wnt signalling in catshark embryos produces skeletal alterations which match in silico predictions. Together, our results suggest that the broad morphological diversity of the distal fin and limb elements arose from the spatial re-organization of a deeply conserved Turing mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.