Evidence map›Paper›PMID 27211240›Full record

ReviewMolecular and biochemical parasitology2016

Mechanisms of host seeking by parasitic nematodes.

Spencer S Gang, Elissa A Hallem

Abstract readReview
In one paragraph

Review in Molecular and biochemical parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. In vivo efficacy of silver nanoparticles againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Development of Bovine Gastric Organoids as a NovelFrontiers in cellular and infection microbiology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Spencer S GangDepartment of Microbiology, Immunology, and Molecular Genetics and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: sgang@ucla.edu.
Elissa A HallemDepartment of Microbiology, Immunology, and Molecular Genetics and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: ehallem@microbio.ucla.edu.

Funding

MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
The neural basis of odor-driven behavior in skin-penetrating parasitic nematodes.DP2DC014596 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HALLEM, ELISSA ANYON · 2014 to 2014
$2.3M
NIAID NIH HHS T32 AI007323NIDCD NIH HHS DP2 DC014596
6 · The paper itself

Abstract

The phylum Nematoda comprises a diverse group of roundworms that includes parasites of vertebrates, invertebrates, and plants. Human-parasitic nematodes infect more than one billion people worldwide and cause some of the most common neglected tropical diseases, particularly in low-resource countries [1]. Parasitic nematodes of livestock and crops result in billions of dollars in losses each year [1]. Many nematode infections are treatable with low-cost anthelmintic drugs, but repeated infections are common in endemic areas and drug resistance is a growing concern with increasing therapeutic and agricultural administration [1]. Many parasitic nematodes have an environmental infective larval stage that engages in host seeking, a process whereby the infective larvae use sensory cues to search for hosts. Host seeking is a complex behavior that involves multiple sensory modalities, including olfaction, gustation, thermosensation, and humidity sensation. As the initial step of the parasite-host interaction, host seeking could be a powerful target for preventative intervention. However, host-seeking behavior remains poorly understood. Here we review what is currently known about the host-seeking behaviors of different parasitic nematodes, including insect-parasitic nematodes, mammalian-parasitic nematodes, and plant-parasitic nematodes. We also discuss the neural bases of these behaviors.

Indexed as

Host-Seeking BehaviorAnimalsHumansNematodaPlantsEntomopathogenic nematodesHost-seeking behaviorOlfactory behaviorParasitic helminthsParasitic nematodesSkin-penetrating nematodes

Identifiers

PMID27211240
PMCPMC4993646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.