ArticleStem cell reports2016
Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation.
Article in Stem cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Dose-resolved control of somatic reprogramming by Rora.Stem cell reports · 2026Article
- YY1-mediated transcriptional regulation of LINC01615 inhibits WNT2 mRNA degradation to promote gastric cancer progression.Scientific reports · 2025Article
- Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction.Stem cell reports · 2025Article
- β-catenin perturbations control differentiation programs in mouse embryonic stem cells.iScience · 2022Article
- Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.Annals of the rheumatic diseases · 2022Article
- Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm.Cells · 2021Review
- Article
- Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells†.Biology of reproduction · 2021Article
- An update on Wnt signaling pathway in cancer.Translational cancer research · 2020Review
- CK19 Promotes Ovarian Cancer Development by Impacting on Wnt/β-Catenin Pathway.OncoTargets and therapy · 2020Article
- Promotion of ovarian cancer cell invasion, migration and colony formation by the miR‑21/Wnt/CD44v6 pathway.Oncology reports · 2019Article
- Review
- Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2.Journal of experimental & clinical cancer research : CR · 2019Article
- Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts.Medicine · 2018Article
- The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency.Genes · 2018Review
- IWP2 impairs the development of porcine somatic cell nuclear transfer embryos via Wnt signaling pathway inactivation.Biomedical reports · 2017Article
- Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.PloS one · 2017Article
- Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts.Journal of cell science · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramming efficiency; however, the dynamics and role of endogenous Wnt/β-catenin signaling in reprogramming remain largely unanswered. Here we identify the upregulation of WNT2 and subsequent β-catenin nuclear accumulation as key events in reprogramming. Transient nuclear accumulation of β-catenin occurs early in MEF reprogramming. Wnt2 is strongly expressed in the early stage of reprogramming. Wnt2 knockdown suppresses the nuclear accumulation of β-catenin and reduces the reprogramming efficiency. WNT2 overexpression promotes β-catenin nuclear accumulation and enhances the reprogramming efficiency. WNT2 contributes to the promotion of cell proliferation. Experiments with several drugs that control the Wnt pathway also indicate the importance of β-catenin nuclear accumulation in reprogramming. Our findings reveal the role of WNT2/β-catenin signaling in reprogramming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.