ArticleCell reports2016
Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- In vivo DNA damage protection during cell migration across confining embryonic tissue environments.Nature cell biology · 2026Article
- Clusters, fingers, and singles: A mechanical landscape of tumor invasion.PLoS computational biology · 2026Article
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- Collective migration modes in development, tissue repair and cancer.Nature reviews. Molecular cell biology · 2025Review
- Self-generated chemotaxis of mixed cell populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Interphase cell morphology defines the mode, symmetry, and outcome of mitosis.Science (New York, N.Y.) · 2025Article
- From neural crest migration to the onset of gangliogenesis.Current topics in developmental biology · 2025Review
- Vinculin is required for interkinetic nuclear migration (INM) and cell cycle progression.The Journal of cell biology · 2024Article
- Polarization and motility of one-dimensional multi-cellular trains.Biophysical journal · 2023Article
- Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature.Development (Cambridge, England) · 2023Article
- Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.Development (Cambridge, England) · 2023Article
- Article
- Who's really in charge: Diverse follower cell behaviors in collective cell migration.Current opinion in cell biology · 2023Review
- Dynamic movement and turnover of extracellular matrices during tissue development and maintenance.Fly · 2022Review
- Notch controls the cell cycle to define leader versus follower identities during collective cell migration.eLife · 2022Article
- Trunk Neural Crest Migratory Position and Asymmetric Division Predict Terminal Differentiation.Frontiers in cell and developmental biology · 2022Article
- Quantitative Analysis of Directional Neural Crest Cell Migration.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body.Developmental biology · 2021Article
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Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Collective cell migration is fundamental for life and a hallmark of cancer. Neural crest (NC) cells migrate collectively, but the mechanisms governing this process remain controversial. Previous analyses in Xenopus indicate that cranial NC (CNC) cells are a homogeneous population relying on cell-cell interactions for directional migration, while chick embryo analyses suggest a heterogeneous population with leader cells instructing directionality. Our data in chick and zebrafish embryos show that CNC cells do not require leader cells for migration and all cells present similar migratory capacities. In contrast, laser ablation of trunk NC (TNC) cells shows that leader cells direct movement and cell-cell contacts are required for migration. Moreover, leader and follower identities are acquired before the initiation of migration and remain fixed thereafter. Thus, two distinct mechanisms establish the directionality of CNC cells and TNC cells. This implies the existence of multiple molecular mechanisms for collective cell migration.
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Registered trials
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