ArticleNeuron2016
Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial.Molecular psychiatry · 2017Trial
- Accumbal Dopamine and Acetylcholine Dynamics during Psychostimulant Sensitization.bioRxiv : the preprint server for biology · 2025Article
- Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic responses of striatal cholinergic interneurons control behavioral flexibility.Science advances · 2024Article
- Orbitofrontal cortex to dorsal striatum circuit is critical for incubation of oxycodone craving after forced abstinence.Addiction biology · 2024Article
- Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward.Frontiers in molecular neuroscience · 2024Article
- Article
- Purinergic P2X7 receptor-mediated inflammation precedes PTSD-related behaviors in rats.Brain, behavior, and immunity · 2023Article
- Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens.Cell reports · 2022Article
- Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes.Cell reports · 2022Article
- Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.Nature communications · 2022Article
- Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning.Molecular psychiatry · 2022Article
- Striatal Cholinergic Signaling in Time and Space.Molecules (Basel, Switzerland) · 2022Review
- Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens.Molecular psychiatry · 2022Review
- Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens.Molecular psychiatry · 2022Review
- Binge alcohol drinking alters the differential control of cholinergic interneurons over nucleus accumbens D1 and D2 medium spiny neurons.Frontiers in cellular neuroscience · 2022Article
- Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement.Nature neuroscience · 2021Article
- The Ventral Tegmental Area to Accumbens GABAergic Projection: Promoting Prediction or Engineering Extinction?Biological psychiatry · 2021Article
- Calcineurin Participation in Hebbian and Homeostatic Plasticity Associated With Extinction.Frontiers in cellular neuroscience · 2021Review
- Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release.Frontiers in synaptic neuroscience · 2021Review
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4 authors.
Funding
Abstract
Despite the fact that cholinergic interneurons are a key cell type within the nucleus accumbens, a relationship between synaptic plasticity and the in vivo activity of cholinergic interneurons remains to be established. Here, we identify a three-way link between the activity of cholinergic interneurons, synaptic plasticity, and learning in mice undergoing the extinction of a cocaine-context association. We found that activity of cholinergic interneurons regulates extinction learning for a cocaine-context association and generates a sustained reduction in glutamatergic presynaptic strength onto medium spiny neurons. Interestingly, activation of cholinergic interneurons does not support reinforcement learning or plasticity by itself, suggesting that these neurons have a modulatory rather than a reinforcing function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.