ArticleNeuron2016
Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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109 citing papers in PubMed, 226 citations in OpenAlex.
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026Article
- An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition inScience advances · 2026Article
- Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila.Biomedical journal · 2026Article
- A highly sensitive genetically encoded red cAMP sensor for multiplex imaging in vivo.Nature communications · 2026Article
- Article
- Octopamine signaling regulates the intracellular pattern of the presynaptic active zone scaffold within Drosophila mushroom body neurons.PLoS biology · 2025Article
- A distinct neural ensemble to integrate contradictory information and form long-term memory inScience advances · 2025Article
- Twists to Classical Conditioning of AdultCold Spring Harbor protocols · 2025Article
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- In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies.Journal of visualized experiments : JoVE · 2025Article
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling.Nature communications · 2024Article
- Reward Bases: A simple mechanism for adaptive acquisition of multiple reward types.PLoS computational biology · 2024Article
- Review
- Article
- Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.Neuron · 2024Article
- Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body.Nature communications · 2024Article
- An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.National science review · 2024Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-γ1pedc>α/β. However, MVP2 neuron output is only essential for expression of short-term aversive memory. Stimulating MVP2 neurons preferentially inhibits the odor-evoked activity of avoidance-directing MBONs and odor-driven avoidance behavior, whereas their inhibition enhances odor avoidance. In contrast, odor-evoked activity of MVP2 neurons is elevated in hungry flies, and their feed-forward inhibition is required for expression of appetitive memory at all times. Moreover, imposing MVP2 activity promotes inappropriate appetitive memory expression in food-satiated flies. Aversive learning and appetitive motivation therefore toggle alternate modes of a common feed-forward inhibitory MVP2 pathway to promote conditioned odor avoidance or approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.