ArticleScientific reports2016
LASSO-based NTCP model for radiation-induced temporal lobe injury developing after intensity-modulated radiotherapy of nasopharyngeal carcinoma.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.The Cochrane database of systematic reviews · 2025Pooled it
- Comparison of radiation-induced temporal lobe injury after helical tomotherapy versus conventional intensity-modulated radiotherapy for nasopharyngeal carcinoma: a propensity score-matched cohort study.Radiation oncology (London, England) · 2026Article
- Using Radiomics and Explainable Ensemble Learning to Predict Radiation Pneumonitis and Survival in NSCLC Patients Post-VMAT.Life (Basel, Switzerland) · 2025Article
- A risk model for predicting partial late radiation-induced injuries in T3-4 nasopharyngeal carcinoma based on dosimetric parameters and clinical factors.Discover oncology · 2025Article
- Radiation-induced temporal lobe necrosis in a nasopharyngeal cancer patient after external beam radiotherapy: a case report and review of literature.Journal of medical case reports · 2025Review
- Potential Risk of Cognitive Impairment Due to Irradiation of Neural Structures in Locally Advanced Nasopharyngeal Cancer Treated by Curative Radiotherapy.Medicina (Kaunas, Lithuania) · 2025Article
- Development of a risk prediction model for radiation dermatitis following proton radiotherapy in head and neck cancer using ensemble machine learning.Radiation oncology (London, England) · 2024Article
- Establishment and risk factor assessment of the abnormal body temperature probability prediction model (ABTP) for dairy cattle.Scientific reports · 2024Article
- MRI-based radiomics models predict cystic brain radionecrosis of nasopharyngeal carcinoma after intensity modulated radiotherapy.Frontiers in neurology · 2024Article
- Predictive accuracy of machine learning for radiation-induced temporal lobe injury in nasopharyngeal carcinoma patients: a systematic review and meta-analysis.Translational cancer research · 2023Article
- Application value of 3D pCASL in early assessment of potential radiation encephalopathy in nasopharyngeal carcinoma patients undergoing radiotherapy.The British journal of radiology · 2023Article
- MRI-based radiomics models for the early prediction of radiation-induced temporal lobe injury in nasopharyngeal carcinoma.Frontiers in neurology · 2023Article
- Assessing the length of hospital stay for patients with myasthenia gravis based on the data mining MARS approach.Frontiers in neurology · 2023Article
- Distribution pattern of medial group retropharyngeal lymph nodes and its implication in optimizing clinical target volume in nasopharyngeal carcinoma.Frontiers in oncology · 2023Article
- Article
- Proton Radiation Therapy for Nasopharyngeal Cancer Patients: Dosimetric and NTCP Evaluation Supporting Clinical Decision.Cancers · 2022Article
- MRI-based radiomics nomogram for predicting temporal lobe injury after radiotherapy in nasopharyngeal carcinoma.European radiology · 2022Article
- Impact of RBE variations on risk estimates of temporal lobe necrosis in patients treated with intensity-modulated proton therapy for head and neck cancer.Acta oncologica (Stockholm, Sweden) · 2022Article
- Half-Brain Delineation for Prediction of Radiation-Induced Temporal Lobe Injury in Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiotherapy.Frontiers in oncology · 2021Article
- Machine-learning based MRI radiomics models for early detection of radiation-induced brain injury in nasopharyngeal carcinoma.BMC cancer · 2020Article
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10 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
We investigated the incidence of temporal lobe injury (TLI) in 132 nasopharyngeal carcinoma (NPC) patients who had undergone intensity-modulated radiotherapy (IMRT) in our hospital between March 2005 and November 2009; and identified significant dosimetric predictors of TLI development. Contrast-enhanced lesions or cysts in the temporal lobes, as detected by magnetic resonance imaging (MRI), were regarded as radiation-induced TLIs. We used the least absolute shrinkage and selection operator (LASSO) method to select Dmax (the maximum point dose) and the D1cc (the top dose delivered to a 1-mL volume) from 15 dose-volume-histogram-associated and four clinically relevant candidate factors; the Dmax and the D1cc were the most significant predictors of TLI development. We drew dose-response curves for Dmax and D1cc. The tolerance dose (TD) for the 5% and 50% probabilities of TLI development were 69.0 ± 1.6 and 82.1 ± 2.4 Gy for Dmax and 62.8 ± 2.2 and 80.9 ± 3.4 Gy for D1cc, respectively. The incidence of TLI in NPC patients after IMRT was higher than expected because the therapeutic window is narrow. High-quality longitudinal studies are needed to gain further insight into the complex spatiotemporal effects of non-uniform irradiation on TLI development in NPC patients.
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