ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2016
Modulatory effects on Drosophila larva hearts: room temperature, acute and chronic cold stress.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- High-throughput single-fly LC-MS/MS for quantitative profiling of biogenic amines in Drosophila.PloS one · 2026Article
- The Effects of Overexpressing K2p Channels in Various Tissues on Physiology and Behaviors.Insects · 2025Article
- Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025Review
- Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function.Journal of visualized experiments : JoVE · 2022Article
- Effect of Temperature on Heart Rate forInsects · 2021Article
- The effects of tricaine mesylate on arthropods: crayfish, crab and Drosophila.Invertebrate neuroscience : IN · 2020Article
- Role of the Insect Neuroendocrine System in the Response to Cold Stress.Frontiers in physiology · 2020Review
- Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larvalBiology open · 2019Article
- The Effects of Chloride Flux onMethods and protocols · 2019Article
- Effect of temperature change on synaptic transmission at crayfish neuromuscular junctions.Biology open · 2018Article
- Physiological Changes as a Measure of Crustacean Welfare under Different Standardized Stunning Techniques: Cooling and Electroshock.Animals : an open access journal from MDPI · 2018Article
- Using optogenetics to assess neuroendocrine modulation of heart rate in Drosophila melanogaster larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ectothermic animals are susceptible to temperature changes such as cold shock with seasons. To survive through a cold shock or season, ectotherms have developed unique strategies. Our interest is focusing on the modulation of physiological functions during cold shock and prolonged cold exposure in the fruit fly. We use Drosophila melanogaster as a model system to investigate cardiac function in response to modulators (5-HT-serotonin, Ach-acetylcholine, OA-octopamine, DA-dopamine and a cocktail of modulators) in acute cold shock and chronic cold shock conditions. Semi-intact larvae are used to provide direct access to the modulators of known concentration in a defined saline. The results show that 10 µM 5HT is the only modulator which maintains heart rate for larva raised at 21 °C and then exposed to acute cold shock (10 °C). The modulators 1 µM OA, 10 µM 5HT, 1 mM Ach, 10 µM Ach and a cocktail of modulators (at 10 µM) increased the heart rate significantly in larvae which were cold conditioned (10 °C for 10 days). HPLC analysis indicated both OA and 5-HT decreased in chronic cold conditioning. The larvae maintain heart function in the cold which may be contributed by low circulating levels of modulators. The larval heart responds better to 5-HT, OA, and Ach in conditioned cold than for acute cold, suggesting some acclimation to cold.
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Registered trials
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