Evidence map›Paper›PMID 27209369›Full record

ArticleBurns : journal of the International Society for Burn Injuries2016

The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn.

Bong-Sung Kim, Christian Stoppe, Gerrit Grieb, Lin Leng, Maor Sauler, David Assis, David Simons, Arne Hendrick Boecker, Wibke Schulte, Marta Piecychna and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns : journal of the International Society for Burn Injuries, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Observational
  2. Review
  3. The role of CD74 in cardiovascular disease.Frontiers in cardiovascular medicine · 2022
    Review
  4. Article
  5. Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Bong-Sung KimDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA; Department of Plastic and Reconstructive Surgery, Hand Surgery - Burn Center, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: bong.kim@rwth-aachen.de.
Christian StoppeInstitute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; Department of Anesthesiology and Intensive Care Medicine, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Gerrit GriebDepartment of Plastic and Reconstructive Surgery, Hand Surgery - Burn Center, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Lin LengDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA.
Maor SaulerPulmonary, Critical Care & Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA.
David AssisDigestive Diseases, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA.
David SimonsInstitute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; German Cancer Research Center, Im Neuenheimer Feld 280, 69121 Heidelberg, Germany.
Arne Hendrick BoeckerDepartment of Plastic and Reconstructive Surgery, Hand Surgery - Burn Center, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Wibke SchulteDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA.
Marta PiecychnaDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA.
Stephan HagerDepartment of Plastic and Reconstructive Surgery, Hand Surgery - Burn Center, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Jürgen BernhagenInstitute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; Institute for Stroke and Dementia Research, Ludwig-Maximilians University Munich, Feodor-Lynen-Straße 17, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377 Munich, Germany.
Norbert PalluaDepartment of Plastic and Reconstructive Surgery, Hand Surgery - Burn Center, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Richard BucalaDepartment of Medicine, Yale University School of Medicine, 300 Cedar Street, 06520 New Haven, CT, USA.
Yale University · USRWTH Aachen University · DEGerman Cancer Research Center · DEMunich Cluster for Systems Neurology · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MIF AND THE HOST RESPONSE TO INFECTIONR01AI042310 · NIAID · YALE UNIVERSITY · PI BUCALA, RICHARD J · 1998 to 2013
$4.3M
MIF and Host Response to InfectionR56AI042310 · NIAID · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2014 to 2014
$426k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI042310NIAID NIH HHS R56 AI042310
6 · The paper itself

Abstract

backgroundWe reported earlier that the cytokine macrophage migration inhibitory factor (MIF) is a potential biomarker in burn injury. In the present study, we investigated the clinical significance of the newly discovered MIF family member d-dopachrome tautomerase (DDT or MIF-2) and their common soluble receptor CD74 (sCD74) in severely burned patients.

methodsDDT and sCD74 serum levels were measured 20 severely burned patients and 20 controls. Serum levels were correlated to the abbreviated burn severity index (ABSI) and total body surface area (TBSA) followed by receiver operating characteristic (ROC) analysis. Data were supported by gene expression dataset analysis of 31 burn patients and 28 healthy controls.

resultsCD74 and DDT were increased in burn patients. Furthermore, CD74 and DDT also were elevated in septic non-survivors when compared to survivors. Serum levels of DDT showed a positive correlation with the ABSI and TBSA in the early stage after burn, and the predictive character of DDT was strongest at 24h. Serum levels of CD74 only correlated with the ABSI 5 days after injury.

conclusionsDDT may assist in the monitoring of clinical outcome and prediction of sepsis during the early post-burn period. Soluble CD74 and MIF, by contrast, have limited value as an early predictor of death due to their delayed response to burn.

Indexed as

AdultAgedAged, 80 and overAntigens, Differentiation, B-LymphocyteBody Surface AreaBurnsCase-Control StudiesFemaleHistocompatibility Antigens Class IIHumansIntramolecular OxidoreductasesMaleMiddle AgedPrognosisROC CurveSepsisAntigens, Differentiation, B-Lymphocytedopachrome isomeraseHistocompatibility Antigens Class IIIntramolecular Oxidoreductasesinvariant chainBiomarkerBurnCD74DDTMIFSepsis

Identifiers

PMID27209369
PMCPMC5010466
OpenAlexW2399314948

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.