ReviewCell calcium2016
Subcellular ROS imaging methods: Relevance for the study of calcium signaling.
Review in Cell calcium, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction.Antioxidants (Basel, Switzerland) · 2022Article
- Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods.International journal of molecular sciences · 2022Review
- The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.Archives of toxicology · 2021Article
- OPA1 Modulates Mitochondrial CaFrontiers in cell and developmental biology · 2021Article
- Acetaldehyde induces phosphorylation of dynamin-related protein 1 and mitochondrial dysfunction via elevating intracellular ROS and CaRedox biology · 2020Article
- Mitochondrial Function in Enamel Development.Frontiers in physiology · 2020Article
- Advance of Seriniquinone Analogues as Melanoma Agents.ACS medicinal chemistry letters · 2019Article
- Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.Cell death and differentiation · 2018Review
- Article
- A Ratiometric and near-Infrared Fluorescent Probe for Imaging CuJournal of fluorescence · 2017Article
- Crosstalk between calcium and reactive oxygen species signaling in cancer.Cell calcium · 2017Review
- Mitochondrially targeted fluorescent redox sensors.Interface focus · 2017Review
- The Mitochondrial Voltage-Dependent Anion Channel 1, CaFrontiers in oncology · 2017Review
- Imaging of Molecular and Developmental Responses to Abiotic Stresses in Reproductive Tissues.Physiologia plantarumReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Recent advances in genetically encoded fluorescent probes have dramatically increased the toolkit available for imaging the intracellular environment. Perhaps the biggest improvements have been made in sensing specific reactive oxygen species (ROS) and redox changes under physiological conditions. The new generation of probes may be targeted to a wide range of subcellular environments. By targeting such probes to compartments and organelle surfaces they may be exposed to environments, which support local signal transduction and regulation. The close apposition of the endoplasmic reticulum (ER) with mitochondria and other organelles forms such a local environment where Ca(2+) dynamics are greatly enhanced compared to the bulk cytosol. We describe here how newly developed genetically encoded redox indicators (GERIs) might be used to monitor ROS and probe their interaction with Ca(2+) at both global and local level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.