Evidence map›Paper›PMID 27209326›Full record

ReviewItalian journal of pediatrics2016

Update on the safety of second generation antipsychotics in youths: a call for collaboration among paediatricians and child psychiatrists.

Simone Pisano, Gennaro Catone, Stefania Veltri, Valentina Lanzara, Marco Pozzi, Emilio Clementi, Raffaella Iuliano, Maria Pia Riccio, Sonia Radice, Massimo Molteni and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Simone PisanoDepartment of Mental and Physical Health and Preventive Medicine, Child and Adolescent Neuropsychiatry Division, Second University of Naples, 80131, Naples, Italy.
Gennaro CatoneDepartment of Mental and Physical Health and Preventive Medicine, Child and Adolescent Neuropsychiatry Division, Second University of Naples, 80131, Naples, Italy.
Stefania VeltriChild Neurology and Psychiatry Unit, Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
Valentina LanzaraDepartment of Mental and Physical Health and Preventive Medicine, Child and Adolescent Neuropsychiatry Division, Second University of Naples, 80131, Naples, Italy.
Marco PozziScientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy.
Emilio ClementiUnit of Clinical Pharmacology, CNR Institute of Neuroscience, Department of Biomedical and Clinical Sciences, L. Sacco University Hospital, Università di Milano, 20157, Milan, Italy.
Raffaella IulianoDepartment of Pediatrics, Hospital "F. Veneziale", Isernia, Italy.
Maria Pia RiccioDepartment of Mental and Physical Health and Preventive Medicine, Child and Adolescent Neuropsychiatry Division, Second University of Naples, 80131, Naples, Italy.
Sonia RadiceUnit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences L Sacco, L. Sacco University Hospital, Università di Milano, 20157, Milan, Italy.
Massimo MolteniScientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy.
Annalisa CapuanoCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Department of Experimental Medicine, Second University of Naples, 80131, Naples, Italy.
Antonella GrittiChild Neuropsychiatry, Faculty of Education, Suor Orsola Benincasa University, Naples, Italy.
Giangennaro CoppolaClinic of Child and Adolescent Neuropsychiatry, Department of Medicine and Surgery, S. Giovanni di Dio and Ruggi d'Aragona Hospital, University of Salerno, Fisciano, Italy.
Annarita MiloneIRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy.
Carmela BravaccioDepartment of Translational Medical Sciences, University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy. carmela.bravaccio@unina.it.
Gabriele MasiIRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the past decade, a substantial increase in the use of second generation antipsychotics (SGAs) has occurred for a number of juvenile psychiatric disorders, often as off-label prescriptions. Although they were thought to be safer than older, first generation antipsychotics, mainly due to a lower risk of neurological adverse reactions, recent studies have raised significant concerns regarding their safety regarding metabolic, endocrinological and cardiovascular side effects. Aim of this paper is to update with a narrative review, the latest findings on safety of SGAs in youths. Results suggest that different SGAs may present different safety profiles. Metabolic adverse events are the most frequent and troublesome, with increasing evidences of heightened risk for type II diabetes mellitus. Results are discussed with specific emphasis on possible strategies of an active monitoring, which could enable both paediatricians and child psychiatrists to a possible prevention, early detection, and a timely management of such effects.

Indexed as

AdolescentAntipsychotic AgentsBasal Ganglia DiseasesChildDiabetes Mellitus, Type 2Drug MonitoringDyslipidemiasHumansLong QT SyndromeOff-Label UsePractice Guidelines as TopicRisk FactorsWeight GainAntipsychotic AgentsAdolescentsAdverse eventsAntipsychoticsChildren

Identifiers

PMID27209326
PMCPMC4875613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.