Evidence map›Paper›PMID 27209305›Full record

ArticleNeurochemical research2016

Increases of Catalase and Glutathione Peroxidase Expressions by Lacosamide Pretreatment Contributes to Neuroprotection Against Experimentally Induced Transient Cerebral Ischemia.

Hyun Young Choi, Joon Ha Park, Bai Hui Chen, Bich Na Shin, Yun Lyul Lee, In Hye Kim, Jeong-Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Moo-Ho Won and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Hyun Young ChoiDepartment of Emergency Medicine, Gangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, 07441, South Korea.
Joon Ha ParkDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Bai Hui ChenDepartment of Physiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 24252, South Korea.
Bich Na ShinDepartment of Physiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 24252, South Korea.
Yun Lyul LeeDepartment of Physiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 24252, South Korea.
In Hye KimDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Jeong-Hwi ChoDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Tae-Kyeong LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Jae-Chul LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Moo-Ho WonDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea. mhwon@kangwon.ac.kr.
Ji Hyeon AhnDepartment of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Hyun-Jin TaeDepartment of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Bing Chun YanInstitute of Integrative Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, 225001, China.
In Koo HwangDepartment of Anatomy and Cell Biology, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea.
Jun Hwi ChoDepartment of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Young-Myeong KimDepartment of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Sung Koo KimDepartment of Pediatrics, Dongtan Sacred Heart Hospital, School of Medicine, Hallym University, Hwaseong, 18450, South Korea. pedkimsk@gmail.com.
Kangwon National University · KRHallym University · KRHallym University Dongtan Sacred Heart Hospital · KRHallym University Kangnam Sacred Heart Hospital · KRSeoul National University · KRYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lacosamide is a new antiepileptic drug which is widely used to treat partial-onset seizures. In this study, we examined the neuroprotective effect of lacosamide against transient ischemic damage and expressions of antioxidant enzymes such as Zn-superoxide dismutase (SOD1), Mn-superoxide dismutase (SOD2), catalase (CAT) and glutathione peroxidase (GPX) in the hippocampal cornu ammonis 1 (CA1) region following 5 min of transient global cerebral ischemia in gerbils. We found that pre-treatment with 25 mg/kg lacosamide protected CA1 pyramidal neurons from transient global cerebral ischemic insult using hematoxylin-eosin staining and neuronal nuclear antigen immunohistochemistry. Transient ischemia dramatically changed expressions of SOD1, SOD2 and GPX, not CAT, in the CA1 pyramidal neurons. Lacosamide pre-treatment increased expressions of CAT and GPX, not SOD1 and 2, in the CA1 pyramidal neurons compared with controls, and their expressions induced by lacosamide pre-treatment were maintained after transient cerebral ischemia. In brief, pre-treatment with lacosamide protected hippocampal CA1 pyramidal neurons from ischemic damage induced by transient global cerebral ischemia, and the lacosamide-mediated neuroprotection may be closely related to increases of CAT and GPX expressions by lacosamide pre-treatment.

Indexed as

AcetamidesAnimalsAntioxidantsBrain IschemiaCatalaseDisease Models, AnimalGerbillinaeGlutathione PeroxidaseHippocampusIschemic Attack, TransientLacosamideMaleNeuronsNeuroprotective AgentsReperfusion InjuryAcetamidesAntioxidantsCatalaseGlutathione PeroxidaseLacosamideNeuroprotective AgentsAntiepileptic drugAntioxidantsLacosamideNeuroprotectionPyramidal neuronsTransient global cerebral ischemia

Identifiers

PMID27209305
OpenAlexW2405260176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.