ArticleJournal of the American Medical Directors Association2016
Gait Performance in Hypertensive Patients on Angiotensin-Converting Enzyme Inhibitors.
Article in Journal of the American Medical Directors Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect of Antihypertensive and Statin Medication Use on Muscle Performance in Community-Dwelling Older Adults Performing Strength Training.Drugs & aging · 2021Trial
- Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians.Molecular and cellular biochemistry · 2025Review
- Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study.The journal of nutrition, health & aging · 2024Article
- Associations Between Hypertension, Angiotensin-Converting Enzyme Inhibitors, and Physical Performance in Very Old Adults: Results from the ilSIRENTE Study.The Journal of frailty & aging · 2024Article
- Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Centrally Acting ACE Inhibitor Use and Physical Performance in Older Adults.The Journal of frailty & aging · 2023Article
- Rewinding sarcopenia: a narrative review on the renin-angiotensin system.Aging clinical and experimental research · 2021Review
- Challenges experienced by patients with hypertension in Ghana: A qualitative inquiry.PloS one · 2021Article
- The effect of polypharmacy on prefrontal cortex activation during single and dual task walking in community dwelling older adults.Pharmacological research · 2019Article
- Polypharmacy and Gait Performance in Community-dwelling Older Adults.Journal of the American Geriatrics Society · 2017Article
- Role of circulating factors in cardiac aging.Journal of thoracic disease · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveTo examine the relationship between angiotensin-converting enzyme inhibitor (ACEI) use and gait performance in older adults.
designCross-sectional survey.
settingCommunity.
participantsA total of 281 community-dwelling older adults with hypertension enrolled in an aging study. MEASUREMENTS: Quantitative variables used to define gait performance included velocity (cm/s), stride length (cm), swing time (s), stride length variability (SD), and swing time variability (SD).
resultsThere were 72 hypertensive participants on ACEIs and 209 were on other antihypertensive medications. Linear regression analysis adjusted for age, sex, and potential confounders revealed that hypertensive participants on an ACEI walked 7.29 cm/s slower (P = .016) and stride length was 6.86 cm shorter (P = .006) compared with those not on ACEIs. There were no significant differences on the other gait variables examined.
conclusionACEI use was associated with worse gait performance in elderly hypertensives. Biological mechanisms need to be explored, and clinicians should consider monitoring gait speed in hypertensive patients on ACEIs.
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