ReviewJournal of endocrinological investigation2016
Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction.
Review in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Clinicopathological characteristics of adrenal tumors in older adults: a cohort study.Frontiers in endocrinology · 2026Article
- Non convulsive status epilepticus caused by panhypopituitarism.Acta neurologica Belgica · 2025Article
- Decompensated Heart Failure Secondary to Hypopituitarism in an Elderly Patient.Internal medicine (Tokyo, Japan) · 2024Article
- Diagnosis and therapeutic approach to bone health in patients with hypopituitarism.Reviews in endocrine & metabolic disorders · 2024Review
- A review of complex hormone regulation in thyroid cancer: novel insights beyond the hypothalamus-pituitary-thyroid axis.Frontiers in endocrinology · 2024Review
- Treating Hypopituitarism in the Over 65s: Review of Clinical Studies.Clinical interventions in aging · 2023Review
- Classic cardiovascular risk factors improve in very elderly hypopituitary patients treated on standard hormone replacement in long term follow- up.Clinical diabetes and endocrinology · 2021Article
- Untargeted LC/MS-Based Metabolic Phenotyping of Hypopituitarism in Young Males.Frontiers in pharmacology · 2021Article
- Acute Secondary Adrenal Insufficiency Misdiagnosed as Acute Cholecystitis.Case reports in endocrinology · 2021Article
- Pituitary macroadenoma presenting as severe hyponatremia: a case report.Journal of medical case reports · 2019Article
- Hypothalamic hypopituitarism secondary to suprasellar metastases from small cell lung cancer: a case report and review of the literature.Journal of medical case reports · 2018Review
- Joseph Boruwlaski: the last court dwarf of the History.Journal of endocrinological investigation · 2018Article
- Effect of hypothyroidism on the hypothalamic-pituitary-ovarian axis and reproductive function of pregnant rats.BMC endocrine disorders · 2018Article
- Sir Jeffrey Hudson, the midget of the Queen Henrietta Marie.Journal of endocrinological investigation · 2018Article
- Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase.Mediators of inflammation · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypopituitarism is an uncommon and under-investigated endocrine disorder in old age since signs and symptoms are unspecific and, at least in part, can be attributed to the physiological effects of aging and related co-morbidities. Clinical presentation is often insidious being characterized by non-specific manifestations, such as weight gain, fatigue, low muscle strength, bradipsychism, hypotension or intolerance to cold. In these circumstances, hypopituitarism is a rarely life-threatening condition, but evolution may be more dramatic as a result of pituitary apoplexy, or when a serious condition of adrenal insufficiency suddenly occurs. Clinical presentation depends on the effects that each pituitary deficit can cause, and on their mutual relationship, but also, inevitably, it depends on the severity and duration of the deficit itself, as well as on the general condition of the patient. Indeed, indications and methods of hormone replacement therapy must include the need to normalize the endocrine profile without contributing to the worsening of intercurrent diseases, such as those of glucose and bone metabolism, and the cardiovascular system, or to the increasing cancer risk. Hormonal requirements of elderly patients are reduced compared to young adults, but a prompt diagnosis and appropriate treatment of pituitary deficiencies are strongly recommended, also in this age range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.