Evidence map›Paper›PMID 27209052›Full record

ArticleAllergology international : official journal of the Japanese Society of Allergology2016

TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens.

Yoshihisa Hiraishi, Aya Nambu, Akiko Shibui, Wakako Nakanishi, Sachiko Yamaguchi, Hideaki Morita, Motoyasu Iikura, Andrew N J McKenzie, Kenji Matsumoto, Katsuko Sudo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergology international : official journal of the Japanese Society of Allergology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Yoshihisa HiraishiLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Aya NambuLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Akiko ShibuiLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Wakako NakanishiLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Sachiko YamaguchiLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hideaki MoritaDepartment of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Motoyasu IikuraDepartment of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Andrew N J McKenzieMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Kenji MatsumotoDepartment of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Katsuko SudoAnimal Research Center, Tokyo Medical University, Tokyo, Japan.
Tatsuya YamasobaDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takahide NagaseDepartment of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Susumu NakaeLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama, Japan. Electronic address: snakae@ims.u-tokyo.ac.jp.
The University of Tokyo · JPNational Center For Child Health and Development · JPSystems Biology Institute · JPMRC Laboratory of Molecular Biology · GBNational Center for Global Health and Medicine · JPTokyo Medical University · JP

Funding

Medical Research Council MC_U105178805Wellcome Trust 100963
6 · The paper itself

Abstract

backgroundT cell immunoglobulin domain and mucin domain-containing molecule 3 (TIM-3), which is preferentially expressed on Th1 cells rather than Th2 cells, is considered to be a negative regulator of Th1 cell function. This suggests that TIM-3 indirectly enhances Th2-type immune responses by suppressing Th1 cell function.

methodsTo investigate TIM-3's possible involvement in Th2-type acute and chronic airway inflammation, wild-type and TIM-3-deficient (TIM-3

resultsDespite constitutive expression of TIM-3 mRNA in the lungs, the number of eosinophils in bronchoalveolar lavage fluids (BALFs) and the score of pulmonary inflammation were comparable between wild-type and TIM-3

conclusionsOur findings indicate that, in mice, TIM-3 is not essential for development of HDM-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM-induced chronic allergic airway inflammation.

Indexed as

AnimalsAntigens, DermatophagoidesBronchoalveolar Lavage FluidCytokinesDisease Models, AnimalHepatitis A Virus Cellular Receptor 2Immunoglobulin EInflammationMiceMice, KnockoutRespiratory Tract DiseasesTh1 CellsTh2 CellsAntigens, DermatophagoidesCytokinesHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Immunoglobulin EAllergyAsthmaHouse dust miteMouseTIM-3

Identifiers

PMID27209052
PMCPMC5074363
OpenAlexW2400504786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.