Evidence map›Paper›PMID 27208808›Full record

ReviewExperimental hematology2016

Lysine-specific histone demethylases in normal and malignant hematopoiesis.

Jaclyn Andricovich, Yan Kai, Alexandros Tzatsos

Open access · bronzeAbstract readReview
In one paragraph

Review in Experimental hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jaclyn AndricovichCancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, George Washington University, Washington DC, USA; George Washington University Cancer Center, School of Medicine and Health Sciences, George Washington University, Washington DC, USA. Electronic address: jandricovich@gwu.edu.
Yan KaiCancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, George Washington University, Washington DC, USA; Department of Physics, George Washington University, Washington DC, USA.
Alexandros TzatsosCancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, George Washington University, Washington DC, USA; George Washington University Cancer Center, School of Medicine and Health Sciences, George Washington University, Washington DC, USA. Electronic address: atzatsos@gwu.edu.
George Washington University · US

Funding

Role of epigenetic regulators in pancreatic cancerR00CA158582 · NCI · GEORGE WASHINGTON UNIVERSITY · PI TZATSOS, ALEXANDROS · 2014 to 2016
$707k
Elucidating and targeting epigenetic oncogenic networks in pancreatic cancerR21CA182662 · NCI · GEORGE WASHINGTON UNIVERSITY · PI TZATSOS, ALEXANDROS · 2014 to 2015
$374k
NCI NIH HHS R00 CA158582NCI NIH HHS R21 CA182662
6 · The paper itself

Abstract

The epigenetic control of gene expression is central to the development of the hematopoietic system and the execution of lineage-specific transcriptional programs. During the last 10 years, mounting evidence has implicated the family of lysine-specific histone demethylases as critical regulators of normal hematopoiesis, whereas their deregulation is found in a broad spectrum of hematopoietic malignancies. Here, we review recent findings on the role of these enzymes in normal and malignant hematopoiesis and highlight how aberrant epigenetic regulation facilitates hematopoietic cell transformation through subversion of cell fate and lineage commitment programs.

Indexed as

AnimalsCell Transformation, NeoplasticGene Expression RegulationHematologic NeoplasmsHematopoiesisHistone DemethylasesHistonesHumansMethylationSignal TransductionHistone DemethylasesHistones

Identifiers

PMID27208808
PMCPMC5100667
OpenAlexW2407053521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.