ReviewNeuroscience and biobehavioral reviews2017
Ascending mechanisms of stress integration: Implications for brainstem regulation of neuroendocrine and behavioral stress responses.
Review in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Gonadotropin-Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress-Induced Activation of the Locus Coeruleus-SAM Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Non-contrast computed tomography at the end of the acute care phase as an additional prognostic tool after aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2026Article
- Toxoplasma gondii infection is associated with changes in chronic outcomes in traumatic brain injury.Translational psychiatry · 2026Observational
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Latrepirdine (Dimebon), a potent 5-HTFrontiers in pharmacology · 2026Article
- Exendin-4 enhances GLP-1 signaling and reduces anxiety-like behaviors in male heroin withdrawal mice.PloS one · 2026Article
- Autonomic dysfunction in multiple system atrophy: from pathophysiology to clinical manifestations.Annals of medicine · 2025Review
- Effect of admission blood glucose on early mortality in patients with pontine hemorrhage.Scientific reports · 2025Article
- Infralimbic prefrontal cortical projections to the autonomic brainstem: quantification of inputs to cholinergic and adrenergic/noradrenergic nuclei.Brain structure & function · 2025Article
- Single-cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress.Journal of neuroendocrinology · 2025Review
- The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis.Trends in neurosciences · 2024Review
- Stress integration by an ascending adrenergic-melanocortin circuit.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women.JAMA network open · 2024Article
- Limited bedding and nesting increases ethanol drinking in female rats.Pharmacology, biochemistry, and behavior · 2024Article
- Consistently increased dorsolateral prefrontal cortex activity during the exposure to acute stressors.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Association between occupational noise and obesity: a retrospective cohort study in China.International archives of occupational and environmental health · 2024Article
- Transcriptome changes in the nucleus of the solitary tract induced by repeated stress, alcohol dependence, or stress-induced drinking in dependent mice.Neuropharmacology · 2024Article
- Hindbrain Adrenergic/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses.Endocrinology · 2023Review
- Adrenergic modulation of melanocortin pathway by hunger signals.Nature communications · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In response to stress, defined as a real or perceived threat to homeostasis or well-being, brain systems initiate divergent physiological and behavioral processes that mobilize energy and promote adaptation. The brainstem contains multiple nuclei that engage in autonomic control and reflexive responses to systemic stressors. However, brainstem nuclei also play an important role in neuroendocrine responses to psychogenic stressors mediated by the hypothalamic-pituitary-adrenocortical axis. Further, these nuclei integrate neuroendocrine responses with stress-related behaviors, significantly impacting mood and anxiety. The current review focuses on the prominent brainstem monosynaptic inputs to the endocrine paraventricular hypothalamic nucleus (PVN), including the periaqueductal gray, raphe nuclei, parabrachial nuclei, locus coeruleus, and nucleus of the solitary tract (NTS). The NTS is a particularly intriguing area, as the region contains multiple cell groups that provide neurochemically-distinct inputs to the PVN. Furthermore, the NTS, under regulatory control by glucocorticoid-mediated feedback, integrates affective processes with physiological status to regulate stress responding. Collectively, these brainstem circuits represent an important avenue for delineating interactions between stress and health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.