ArticlePlant physiology2016
A Single Amino-Acid Substitution in the Sodium Transporter HKT1 Associated with Plant Salt Tolerance.
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Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 93 citations in OpenAlex.
- Employing AlphaFold and TED to explore the structural impacts of stress-associated mutations in rice.Bioinformatics advances · 2026Article
- A natural 294-bp indel in the VviHKT1;1 proximal promoter influences the salt resistance of VviHKT1;1-overexpressing Arabidopsis.Journal of plant research · 2025Article
- Characterization of the NaPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- From swamp to field: how genes from mangroves and its associates can enhance crop salinity tolerance.Molecular biology reports · 2024Review
- Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters.Nature plants · 2024Article
- Recent Advances in Tomato Gene Editing.International journal of molecular sciences · 2024Review
- The HKT1 NaScience advances · 2023Article
- A novel high-affinity potassium transporter SeHKT1;2 from halophyteFrontiers in plant science · 2023Article
- The transcription factor OsMYBc and an E3 ligase regulate expression of a K+ transporter during salt stress.Plant physiology · 2022Article
- Transcriptome-Wide Analysis Revealed the Potential of the High-Affinity Potassium Transporter (Bioengineering (Basel, Switzerland) · 2022Article
- Divergence in the ABA gene regulatory network underlies differential growth control.Nature plants · 2022Article
- Mechanism of high affinity potassium transporter (HKT) towards improved crop productivity in saline agricultural lands.3 Biotech · 2022Review
- Salt stress proteins in plants: An overview.Frontiers in plant science · 2022Review
- Mechanisms of Salt Tolerance and Molecular Breeding of Salt-Tolerant Ornamental Plants.Frontiers in plant science · 2022Review
- Unlocking Allelic Diversity for Sustainable Development of Salinity Stress Tolerance in Rice.Current genomics · 2021Review
- Genetic, Epigenetic, Genomic and Microbial Approaches to Enhance Salt Tolerance of Plants: A Comprehensive Review.Biology · 2021Review
- HKT sodium and potassium transporters in Arabidopsis thaliana and related halophyte species.Physiologia plantarum · 2021Review
- Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation.International journal of molecular sciences · 2021Review
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Authors and funding
16 authors at 5 institutions in 5 countries.
Akhtar AliDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Natalia RaddatzDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).ORCID 0000-0002-1801-4131
Rashid AmanDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Songmi KimDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).ORCID 0000-0002-9667-4055
Hyeong Cheol ParkDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Masood JanDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Dongwon BaekDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Irfan Ullah KhanDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Dong-Ha OhDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Sang Yeol LeeDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Ray A BressanDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Keun Woo LeeDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Albino MaggioDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).
Jose M PardoDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).ORCID 0000-0003-4510-8624
Hans J BohnertDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.).ORCID 0000-0003-3749-4959
Dae-Jin YunDivision of Applied Life Science (BK21 Plus Program), Gyeongsang National University, Jinju 660-701, Republic of Korea (A.A., R.A., S.K., M.J., D.B., I.U.K., S.Y.L., K.W.L., H.J.B., D.-J.Y.); Plant Biophysics, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, Carretera M-40, km 37.7, E-28223 Pozuelo de Alarcón Madrid (N.R.);Division of Ecological Adaptation Research, National Institute of Ecology (NIE), Seocheon 325-813, Republic of Korea (H.C.P.); Department of Biology, Louisiana State University, Baton Rouge, Louisiana 70803 (D.-H.O.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010 (R.A.B.);Department of Agriculture, University of Naples Federico II, Via Universita` 100, Portici, I-80055, Italy (A.M.);Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Cientificas, 41092 Sevilla, Spain (J.M.P.); College of Science, King Abdulaziz University, Jeddah 21589, KSA (H.J.B.); and Department of Plant Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801 (H.J.B.) djyun@gnu.ac.kr.
Gyeongsang National University · KRCentre for Plant Biotechnology and Genomics · ESConsejo Superior de Investigaciones Científicas · ESLouisiana State University · USPurdue University West Lafayette · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
A crucial prerequisite for plant growth and survival is the maintenance of potassium uptake, especially when high sodium surrounds the root zone. The Arabidopsis HIGH-AFFINITY K(+) TRANSPORTER1 (HKT1), and its homologs in other salt-sensitive dicots, contributes to salinity tolerance by removing Na(+) from the transpiration stream. However, TsHKT1;2, one of three HKT1 copies in Thellungiella salsuginea, a halophytic Arabidopsis relative, acts as a K(+) transporter in the presence of Na(+) in yeast (Saccharomyces cerevisiae). Amino-acid sequence comparisons indicated differences between TsHKT1;2 and most other published HKT1 sequences with respect to an Asp residue (D207) in the second pore-loop domain. Two additional T salsuginea and most other HKT1 sequences contain Asn (n) in this position. Wild-type TsHKT1;2 and altered AtHKT1 (AtHKT1(N-D)) complemented K(+)-uptake deficiency of yeast cells. Mutant hkt1-1 plants complemented with both AtHKT1(N) (-) (D) and TsHKT1;2 showed higher tolerance to salt stress than lines complemented by the wild-type AtHKT1 Electrophysiological analysis in Xenopus laevis oocytes confirmed the functional properties of these transporters and the differential selectivity for Na(+) and K(+) based on the n/d variance in the pore region. This change also dictated inward-rectification for Na(+) transport. Thus, the introduction of Asp, replacing Asn, in HKT1-type transporters established altered cation selectivity and uptake dynamics. We describe one way, based on a single change in a crucial protein that enabled some crucifer species to acquire improved salt tolerance, which over evolutionary time may have resulted in further changes that ultimately facilitated colonization of saline habitats.
Indexed as
Amino Acid SubstitutionAnimalsArabidopsisArabidopsis ProteinsBrassicaceaeCationsCation Transport ProteinsFemaleModels, MolecularOocytesPlants, Genetically ModifiedSaccharomyces cerevisiaeSalt ToleranceSymportersXenopus laevisArabidopsis ProteinsCationsCation Transport ProteinsHKT1 protein, ArabidopsisSymporters
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