ArticlePlant physiology2016
Arabidopsis NATA1 Acetylates Putrescine and Decreases Defense-Related Hydrogen Peroxide Accumulation.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Integration of meta-analysis, machine learning and systems biology approach for investigating the transcriptomic response to drought stress in Populus species.Scientific reports · 2023Pooled it
- Discovery of regulatory complexes in Arabidopsis via protein-metabolite mapping during Pseudomonas infection.Plant physiology · 2026Article
- Local adaptation of both plant and pathogen: an arms-race compromise in switchgrass rust.The New phytologist · 2025Article
- KAKU4 regulates leaf senescence through modulation of H3K27me3 deposition in the Arabidopsis genome.BMC plant biology · 2024Article
- Piriformospora indica recruits host-derived putrescine for growth promotion in plants.Plant physiology · 2022Article
- Genome-Wide Characterization of the Methyl CpG Binding Domain-Containing Proteins in Watermelon and Functional Analysis of Their Roles in Disease Resistance Through Ectopic Overexpression inFrontiers in plant science · 2022Article
- The transcription factor ORA59 exhibits dual DNA binding specificity that differentially regulates ethylene- and jasmonic acid-induced genes in plant immunity.Plant physiology · 2021Article
- Article
- Plant Unsaturated Fatty Acids: Multiple Roles in Stress Response.Frontiers in plant science · 2020Review
- Low Temperature Enhances Plant Immunity via Salicylic Acid Pathway Genes That Are Repressed by Ethylene.Plant physiology · 2020Article
- Drought-responsive genes, late embryogenesis abundant group3 (LEA3) and vicinal oxygen chelate, function in lipid accumulation in Brassica napus and Arabidopsis mainly via enhancing photosynthetic efficiency and reducing ROS.Plant biotechnology journal · 2019Article
- Metabolic diversification of nitrogen-containing metabolites by the expression of a heterologous lysine decarboxylase gene in Arabidopsis.The Plant journal : for cell and molecular biology · 2019Article
- Genetically Modified Heat Shock Protein90s and Polyamine Oxidases inPlants (Basel, Switzerland) · 2019Article
- Phevamine A, a small molecule that suppresses plant immune responses.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Localized Pseudomonas syringae Infection Triggers Systemic Clock Responses in Arabidopsis.Current biology : CB · 2018Article
- Regulation of Long Noncoding RNAs Responsive to Phytoplasma Infection inInternational journal of genomics · 2018Article
- Making a Better Home: Modulation of Plant Defensive Response byFrontiers in plant science · 2018Article
- Interplay of Pathogen-Induced Defense Responses and Symbiotic Establishment inFrontiers in microbiology · 2017Article
- Coronatine Inhibits Stomatal Closure through Guard Cell-Specific Inhibition of NADPH Oxidase-Dependent ROS Production.Frontiers in plant science · 2016Article
- The loss-of-function of AtNATA2 enhances AtADC2-dependent putrescine biosynthesis and priming, improving growth and salinity tolerance in Arabidopsis.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosynthesis of the polyamines putrescine, spermidine, and spermine is induced in response to pathogen infection of plants. Putrescine, which is produced from Arg, serves as a metabolic precursor for longer polyamines, including spermidine and spermine. Polyamine acetylation, which has important regulatory functions in mammalian cells, has been observed in several plant species. Here we show that Arabidopsis (Arabidopsis thaliana) N-ACETYLTRANSFERASE ACTIVITY1 (NATA1) catalyzes acetylation of putrescine to N-acetylputrescine and thereby competes with spermidine synthase for a common substrate. NATA1 expression is strongly induced by the plant defense signaling molecule jasmonic acid and coronatine, an effector molecule produced by DC3000, a Pseudomonas syringae strain that initiates a virulent infection in Arabidopsis ecotype Columbia-0. DC3000 growth is reduced in nata1 mutant Arabidopsis, suggesting a role for NATA1-mediated putrescine acetylation in suppressing antimicrobial defenses. During infection by P. syringae and other plant pathogens, polyamine oxidases use spermidine and spermine as substrates for the production of defense-related H2O2 Compared to wild-type Columbia-0 Arabidopsis, the response of nata1mutants to P. syringae infection includes reduced accumulation of acetylputrescine, greater abundance of nonacetylated polyamines, elevated H2O2 production by polyamine oxidases, and higher expression of genes related to pathogen defense. Together, these results are consistent with a model whereby P. syringae growth is improved in a targeted manner through coronatine-induced putrescine acetylation by NATA1.
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