ArticlePlant physiology2016
Cytokinin Determines Thiol-Mediated Arsenic Tolerance and Accumulation.
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Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- ARR1 and ARR12 negatively regulate arsenic stress tolerance by controlling flavonoid metabolism in Arabidopsis.Planta · 2026Article
- Selenium Alleviates Cadmium Toxicity in Pepper (Plants (Basel, Switzerland) · 2025Article
- Phytohormone and Amino Acid Changes in Cherry Radish as Metabolic Adaptive Response to Arsenic Single and Multi-Contamination.Biomolecules · 2025Article
- Phytohormones-mediated strategies for mitigation of heavy metals toxicity in plants focused on sustainable production.Plant cell reports · 2024Review
- Phytochelatins: Sulfur-Containing Metal(loid)-Chelating Ligands in Plants.International journal of molecular sciences · 2023Review
- Molecular insight into arsenic uptake, transport, phytotoxicity, and defense responses in plants: a critical review.Planta · 2022Review
- Is Genetic Engineering a Route to Enhance Microalgae-Mediated Bioremediation of Heavy Metal-Containing Effluents?Molecules (Basel, Switzerland) · 2022Review
- Arsenic perception and signaling: The yet unexplored world.Frontiers in plant science · 2022Review
- Cytokinin and abiotic stress tolerance -What has been accomplished and the way forward?Frontiers in genetics · 2022Review
- Application of sulphate and cytokinin in assisted arsenic phytoextraction by industrial Cannabis sativa L.Environmental science and pollution research international · 2021Article
- Coordinated cytokinin signaling and auxin biosynthesis mediates arsenate-induced root growth inhibition.Plant physiology · 2021Article
- Auxins and Cytokinins Regulate Phytohormone Homeostasis and Thiol-Mediated Detoxification in the Green Alga Acutodesmus obliquus Exposed to Lead Stress.Scientific reports · 2020Article
- Response of cytokinins and nitrogen metabolism in the fronds of Pteris sp. under arsenic stress.PloS one · 2020Article
- Foliar uptake of arsenic nanoparticles by spinach: an assessment of physiological and human health risk implications.Environmental science and pollution research international · 2019Article
- Arsenic forms in phytoextraction of this metalloid in organs of 2-year-old Acer platanoides seedlings.Environmental science and pollution research international · 2018Article
- Cytokinin at the Crossroads of Abiotic Stress Signalling Pathways.International journal of molecular sciences · 2018Review
- Root Engineering in Barley: Increasing Cytokinin Degradation Produces a Larger Root System, Mineral Enrichment in the Shoot and Improved Drought Tolerance.Plant physiology · 2018Article
- Genomics of Metal Stress-Mediated Signalling and Plant Adaptive Responses in Reference to Phytohormones.Current genomics · 2017Review
- GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic.Scientific reports · 2017Article
- The Journey of Arsenic from Soil to Grain in Rice.Frontiers in plant science · 2017Review
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Authors and funding
13 authors at 6 institutions in 2 countries.
Thotegowdanapalya C MohanDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).ORCID 0000-0001-8425-251X
Gabriel CastrilloDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Cristina NavarroDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Sonia Zarco-FernándezDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Eswarayya RamireddyDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).ORCID 0000-0002-5666-8865
Cristian MateoDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Angel M ZamarreñoDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).ORCID 0000-0003-1966-0239
Javier Paz-AresDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Riansares MuñozDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Jose M García-MinaDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).ORCID 0000-0001-6352-9612
Luis E HernándezDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).ORCID 0000-0003-3492-5813
Thomas SchmüllingDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.).
Antonio LeyvaDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain (T.C.M., G.C., C.N., C.M., J.P.-A., A.L.); Department of Analytical Chemistry, School of Chemical Sciences, Universidad Complutense de Madrid, Madrid, Spain (S.Z.-F., R.M.); Institute of Biology/Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universität Berlin, Albrecht-Thaer-Weg 6, D-14195 Berlin, Germany (E.R., T.S.); Department of Environmental Biology (Agricultural Chemistry and Biology Group), Faculty of Sciences, University of Navarra, Sciencies Building, 31008 Pamplona, Spain (A.M.Z., J.M.G.-M.); and Departamento de Biología, Universidad Autónoma de Madrid, Edif. de Biológicas BS13, Campus de Cantoblanco, 28049 Madrid, Spain (L.E.H.) aleyva@cnb.csic.es.
Universidad Complutense de Madrid · ESUniversidad de Navarra · ESConsejo Superior de Investigaciones Científicas · ESCentro Nacional de Biotecnología · ESFreie Universität Berlin · DEUniversidad Autónoma de Madrid · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of arsenic in soil and water is a constant threat to plant growth in many regions of the world. Phytohormones act in the integration of growth control and stress response, but their role in plant responses to arsenic remains to be elucidated. Here, we show that arsenate [As(V)], the most prevalent arsenic chemical species in nature, causes severe depletion of endogenous cytokinins (CKs) in the model plant Arabidopsis (Arabidopsis thaliana). We found that CK signaling mutants and transgenic plants with reduced endogenous CK levels showed an As(V)-tolerant phenotype. Our data indicate that in CK-depleted plants exposed to As(V), transcript levels of As(V)/phosphate-transporters were similar or even higher than in wild-type plants. In contrast, CK depletion provoked the coordinated activation of As(V) tolerance mechanisms, leading to the accumulation of thiol compounds such as phytochelatins and glutathione, which are essential for arsenic sequestration. Transgenic CK-deficient Arabidopsis and tobacco lines show a marked increase in arsenic accumulation. Our findings indicate that CK is an important regulatory factor in plant adaptation to arsenic stress.
Indexed as
Adaptation, PhysiologicalArsenicButhionine SulfoximineCytokininsDown-RegulationGene Expression Regulation, PlantGlutathioneInactivation, MetabolicPhenotypePhytochelatinsSulfhydryl CompoundsUp-RegulationArsenicButhionine SulfoximineCytokininsGlutathionePhytochelatinsSulfhydryl Compounds
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