ArticlePlant physiology2016
mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO1.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Temporal regulation of vegetative phase change in plants.Developmental cell · 2024Review
- The N-terminal extension of Arabidopsis ARGONAUTE 1 is essential for microRNA activities.PLoS genetics · 2023Article
- Role of miRNAs in sucrose stress response, reactive oxygen species, and anthocyanin biosynthesis inFrontiers in plant science · 2023Article
- Differential expression profiling of microRNAs and their target genes during wheat-Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species.Planta · 2021Article
- HASTY, the Arabidopsis EXPORTIN5 ortholog, regulates cell-to-cell and vascular microRNA movement.The EMBO journal · 2021Article
- Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells.RNA biology · 2021Review
- Abiotic Stress-Responsive miRNA and Transcription Factor-Mediated Gene Regulatory Network inFrontiers in genetics · 2021Article
- Dynamic distribution of ARGONAUTE1 (AGO1) and ARGONAUTE4 (AGO4) in Hyacinthus orientalis L. pollen grains and pollen tubes growing in vitro.Protoplasma · 2020Article
- Widespread Exon Junction Complex Footprints in the RNA Degradome Mark mRNA Degradation before Steady State Translation.The Plant cell · 2020Article
- Post-transcriptional regulation of several biological processes involved in latex production inPeerJ · 2020Article
- Plant microRNAs: biogenesis, gene silencing, web-based analysis tools and their use as molecular markers.3 Biotech · 2019Review
- Genome-scale, single-cell-type resolution of microRNA activities within a whole plant organ.The EMBO journal · 2019Article
- Too Many False Targets for MicroRNAs: Challenges and Pitfalls in Prediction of miRNA Targets and Their Gene Ontology in Model and Non-model Organisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- A Suppressor Screen for AGO1 Degradation by the Viral F-Box P0 Protein Uncovers a Role for AGO DUF1785 in sRNA Duplex Unwinding.The Plant cell · 2018Article
- Article
- Nanotechnology based approaches for detection and delivery of microRNA in healthcare and crop protection.Journal of nanobiotechnology · 2018Review
- Threshold-dependent repression of SPL gene expression by miR156/miR157 controls vegetative phase change in Arabidopsis thaliana.PLoS genetics · 2018Article
- Respective Contributions of URT1 and HESO1 to the Uridylation of 5' Fragments Produced From RISC-Cleaved mRNAs.Frontiers in plant science · 2018Article
- Heat-shock protein 40 is the key farnesylation target in meristem size control, abscisic acid signaling, and drought resistance.Genes & development · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression in animals and plants. They guide RNA-induced silencing complexes to complementary target mRNA, thereby mediating mRNA degradation or translational repression. ARGONAUTE (AGO) proteins bind directly to miRNAs and may catalyze cleavage (slicing) of target mRNAs. In animals, miRNA target degradation via slicing occurs only exceptionally, and target mRNA decay is induced via AGO-dependent recruitment of deadenylase complexes. Conversely, plant miRNAs generally direct slicing of their targets, but it is unclear whether slicer-independent mechanisms of target mRNA decay also exist, and, if so, how much they contribute to miRNA-induced mRNA decay. Here, we compare phenotypes and transcript profiles of ago1 null and slicer-deficient mutants in Arabidopsis (Arabidopsis thaliana). We also construct conditional loss-of-function mutants of AGO1 to allow transcript profiling in true leaves. Although phenotypic differences between ago1 null and slicer-deficient mutants can be discerned, the results of both transcript profiling approaches indicate that slicer activity is required for mRNA repression of the vast majority of miRNA targets. A set of genes exhibiting up-regulation specifically in ago1 null, but not in ago1 slicer-deficient mutants was also identified, leaving open the possibility that AGO1 may have functions in gene regulation independent of small RNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.