ArticleProceedings of the National Academy of Sciences of the United States of America2016
Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- Comparative Proteomics Highlights that GenX Exposure Leads to Metabolic Defects and Inflammation in Astrocytes.Environmental science & technology · 2024Article
- Effect of Dietary Restriction on Gut Microbiota and Brain-Gut Short Neuropeptide F in Mud Crab,Animals : an open access journal from MDPI · 2024Article
- A novel memristive neuron model and its energy characteristics.Cognitive neurodynamics · 2024Article
- Short neuropeptide F in integrated insect physiology.Journal of Zhejiang University. Science. B · 2024Review
- Markers and mechanisms of death inFrontiers in aging · 2023Article
- Review
- Article
- Nutrient Sensing via Gut inInternational journal of molecular sciences · 2022Review
- New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity.Frontiers in molecular neuroscience · 2022Review
- Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- MAPK-directed activation of the whitefly transcription factorProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Physiological and Pathological Regulation of Peripheral Metabolism by Gut-Peptide Hormones inFrontiers in physiology · 2020Review
- The Role of Peptide Hormones in Insect Lipid Metabolism.Frontiers in physiology · 2020Review
- Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates.Frontiers in endocrinology · 2019Review
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- Rapid Communication: Porcine CRTC3 gene clone, expression pattern, and its regulatory role in intestinal epithelial cells.Journal of animal science · 2018Article
- Intermittent Fasting: Is the Wait Worth the Weight?Current obesity reports · 2018Review
- Metabolic Effects of Intermittent Fasting.Annual review of nutrition · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The starvation-inducible coactivator cAMP response element binding protein (CREB)-cAMP-regulated transcription coactivator (Crtc) has been shown to promote starvation resistance in Drosophila by up-regulating CREB target gene expression in neurons, although the underlying mechanism is unclear. We found that Crtc and its binding partner CREB enhance energy homeostasis by stimulating the expression of short neuropeptide F (sNPF), an ortholog of mammalian neuropeptide Y, which we show here is a direct target of CREB and Crtc. Neuronal sNPF was found to promote energy homeostasis via gut enterocyte sNPF receptors, which appear to maintain gut epithelial integrity. Loss of Crtc-sNPF signaling disrupted epithelial tight junctions, allowing resident gut flora to promote chronic increases in antimicrobial peptide (AMP) gene expression that compromised energy balance. Growth on germ-free food reduced AMP gene expression and rescued starvation sensitivity in Crtc mutant flies. Overexpression of Crtc or sNPF in neurons of wild-type flies dampens the gut immune response and enhances starvation resistance. Our results reveal a previously unidentified tolerance defense strategy involving a brain-gut pathway that maintains homeostasis through its effects on epithelial integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.