Evidence map›Paper›PMID 27208064›Full record

ReviewClinical cancer research : an official journal of the American Association for Cancer Research2016

Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology.

Lacey R McNally, Megan Mezera, Desiree E Morgan, Peter J Frederick, Eddy S Yang, Isam-Eldin Eltoum, William E Grizzle

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 105 citations in OpenAlex.

  1. Assessment of Breast Tumors Using Multispectral Optoacoustic Tomography in a Surgical Setting.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lacey R McNallyDepartment of Medicine, University of Louisville, Louisville, Kentucky. lacey_mcnally@hotmail.com.
Megan MezeraDepartment of Radiation Oncology, University of Louisville, Louisville, Kentucky.
Desiree E MorganDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Peter J FrederickDepartment of Gynecology Oncology, Roswell Park Cancer Institute, Buffalo, New York.
Eddy S YangDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
Isam-Eldin EltoumDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
William E GrizzleDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · USUniversity of Louisville · USRoswell Park Comprehensive Cancer Center · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
UAB Rexinoids for Breast Cancer PreventionP50CA089019 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRIZZLE, WILLIAM E. · 2000 to 2011
$26.0M
UAB / UMN SPORE in Pancreatic CancerP50CA101955 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J · 2010 to 2014
$11.1M
Virus adjunctive therapies for pancreatic cancerP20CA101955 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J. · 2003 to 2007
$4.6M
Collaborative Human Tissue NetworkUM1CA183728 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRIZZLE, WILLIAM E. · 2014 to 2018
$3.7M
NCI NIH HHS P20 CA101955NCI NIH HHS P30 CA013148NCI NIH HHS P50 CA089019NCI NIH HHS P50 CA101955NCI NIH HHS UM1 CA183728
6 · The paper itself

Abstract

Accurate detection and characterization of cancers are key for providing timely intervention and effective treatments. Current imaging technologies are particularly limited when it comes to detecting very small tumors in vivo, i.e., very early cancers or metastases, differentiating viable tumor from surrounding dead tumor tissue, and evaluating tumor metabolism within tissue. Optoacoustic imaging offers potential solutions to these imaging problems because of its ability to image optical absorption properties of both intrinsic tissue chromophores and exogenous contrast agents without the involvement of ionizing radiation. Optoacoustic imaging uses pulsed laser to induce localized thermoelastic expansion that generates acoustic waves detectable by an ultrasound transducer. To date, multispectral optoacoustic tomography (MSOT) has primarily been used in preclinical research; however, its use in translational and clinical research is expanding. This review focuses on current and emerging applications of optoacoustic imaging for molecular imaging of cancer using both exogenous and endogenous contrast agents and sheds light on potential future clinical applications. Clin Cancer Res; 22(14); 3432-9. ©2016 AACR.

Indexed as

AnimalsHumansMedical OncologyNeoplasmsPhotoacoustic TechniquesTomography, Optical

Identifiers

PMID27208064
PMCPMC5046137
OpenAlexW2397824795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.