ArticleJournal of the American Heart Association2016
Carotid Intima-Media Thickness and Arterial Stiffness and the Risk of Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study, Multi-Ethnic Study of Atherosclerosis (MESA), and the Rotterdam Study.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 99 citations in OpenAlex.
- One-year Aerobic Interval Training Improves Endothelial Dysfunction in Patients with Atrial Fibrillation: A Randomized Trial.Internal medicine (Tokyo, Japan) · 2023Trial
- Incidence of atrial fibrillation in elderly patients with type 2 diabetes mellitus.BMJ open diabetes research & care · 2022Trial
- Associations of Lipoprotein(a) Levels With Incident Atrial Fibrillation and Ischemic Stroke: The ARIC (Atherosclerosis Risk in Communities) Study.Journal of the American Heart Association · 2017Trial
- Association of estimated pulse wave velocity with all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from MIMIC IV3.0.Scientific reports · 2026Article
- Review
- Etiologic Types and Complications of Diabetes Mellitus in Newly Diagnosed Patients at Health Institutions in Bulawayo, Zimbabwe: Protocol for a Cross-Sectional and Prospective Observational Study.JMIR research protocols · 2026Observational
- Bidirectional relationships between increased arterial stiffness and atrial fibrillation.Frontiers in cardiovascular medicine · 2026Article
- Increased Pre-Transplant Carotid Intima-Media Thickness Is Associated with Early Post-Transplant Atrial Fibrillation, Stroke, and Reduced Survival After Heart Transplantation.Life (Basel, Switzerland) · 2025Article
- Macrovascular Involvement in Systemic Sclerosis: Association Between Carotid Ultrasound Hemodynamics Parameters and Digital Ulcers.Clinics and practice · 2025Article
- Carotid artery stiffness mechanisms, heart failure events, and atrial fibrillation in MESA: the Multi-Ethnic Study of Atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2025Article
- Arterial Stiffness and Markers of Atrial Myopathy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025Article
- Shear Wave Elastography for Carotid Artery Stiffness: Ready for Prime Time?Diagnostics (Basel, Switzerland) · 2025Review
- Exploring the Mechanisms of EDCs-Induced Metabolic Disorders in Humans Using Network Toxicology and Molecular Docking.NAM journal · 2025Article
- Atrial Fibrillation in Patients with Very High Risk for Stroke and Adverse Events-Insights from the Observational ARENA Study.Journal of clinical medicine · 2024Article
- Risk of Heart Disease in Patients With Amputation: A Nationwide Cohort Study in South Korea.Journal of the American Heart Association · 2024Article
- The association between pulse wave velocity and pregnancy-associated diseases: A systematic review and meta-analysis.Heliyon · 2024Article
- Management of ischaemic stroke survivors in primary care setting: the road to holistic care.Internal and emergency medicine · 2024Review
- Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions-A Review from the VascAgeNet COST Action.Journal of clinical medicine · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Assessment of aortic stiffness during atrial fibrillation: solutions and considerations.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundWe evaluated the association of carotid intima-media thickness (cIMT), carotid plaque, carotid distensibility coefficient (DC), and aortic pulse wave velocity (PWV) with incident atrial fibrillation (AF) and their role in improving AF risk prediction beyond the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)-AF risk score. METHODS AND
resultsWe analyzed data from 3 population-based cohort studies: Atherosclerosis Risk in Communities (ARIC) Study (n=13 907); Multi-Ethnic Study of Atherosclerosis (MESA; n=6640), and the Rotterdam Study (RS; n=5220). We evaluated the association of arterial indices with incident AF and computed the C-statistic, category-based net reclassification improvement (NRI), and relative integrated discrimination improvement (IDI) of incorporating arterial indices into the CHARGE-AF risk score (age, race, height weight, systolic and diastolic blood pressure, antihypertensive medication use, smoking, diabetes, previous myocardial infarction, and previous heart failure). Higher cIMT (meta-analyzed hazard ratio [95% CI] per 1-SD increment, 1.12 [1.08-1.16]) and presence of carotid plaque (1.30 [1.19-1.42]) were associated with higher AF incidence after adjustment for CHARGE-AF risk-score variables. Lower DC and higher PWV were associated with higher AF incidence only after adjustment for the CHARGE-AF risk-score variables excepting height, weight, and systolic and diastolic blood pressure. Addition of cIMT or carotid plaque marginally improved CHARGE-AF score prediction as assessed by the relative IDI (estimates, 0.025-0.051), but not when assessed with the C-statistic and NRI.
conclusionsHigher cIMT, presence of carotid plaque, and greater arterial stiffness are associated with higher AF incidence, indicating that atherosclerosis and arterial stiffness play a role in AF etiopathogenesis. However, arterial indices only modestly improve AF risk prediction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.