Trial reportThe international journal of neuropsychopharmacology2016
Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial.
Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 9 pooled it
7.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 9 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- A systematic review of transcranial magnetic stimulation for generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder.BMC psychiatry · 2026Pooled it
- Optimizing non-invasive brain stimulation for obsessive-compulsive disorder: a systematic review of protocol heterogeneity, personalized targets, and adjunctive efficacy.BMC psychiatry · 2026Pooled it
- Effectiveness of low-frequency, non-navigated repetitive transcranial magnetic stimulation for obsessive-compulsive disorder: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Circuit-based neuromodulation for obsessive-compulsive disorder: a systematic review, meta-analysis, and translational case study.Journal of psychiatry & neuroscience : JPN · 2026Pooled it
- Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation Across Mental Disorders: A Systematic Review and Dose-Response Meta-Analysis.JAMA network open · 2024Pooled it
- Efficacy of Repetitive Transcranial Magnetic Stimulation on Comorbid Anxiety and Depression Symptoms in Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Sham-Controlled Trials.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Pooled it
- Efficacy and tolerability of repetitive transcranial magnetic stimulation for the treatment of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis.Translational psychiatry · 2021Pooled it
- Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review.Current neuropharmacology · 2019Pooled it
- A Meta-Analysis of the Effectiveness of Different Cortical Targets Used in Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Obsessive-Compulsive Disorder (OCD).The Psychiatric quarterly · 2018Pooled it
- RTMS Versus Fluvoxamine in the Treatment of OCD: A Randomized Open-label Pilot Study.International journal of medical sciences · 2026Trial
- A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder.Neural plasticity · 2023Trial
- Continuous theta burst stimulation over the bilateral supplementary motor area in obsessive-compulsive disorder treatment: A clinical randomized single-blind sham-controlled trial.European psychiatry : the journal of the Association of European Psychiatrists · 2022Trial
- Real-Time Tractography-Assisted Neuronavigation for Transcranial Magnetic Stimulation.Human brain mapping · 2025Article
- Metaanalysis of Repetitive Transcranial Magnetic Stimulation (rTMS) Efficacy for OCD Treatment: The Impact of Stimulation Parameters, Symptom Subtype and rTMS-Induced Electrical Field.Journal of clinical medicine · 2024Review
- Impact of Titanium Skull Plate on Transcranial Magnetic Stimulation: Analysis of Induced Electric Fields.Life (Basel, Switzerland) · 2024Article
- Neurotransmitter system gene variants as biomarkers for the therapeutic efficacy of rTMS and SSRIs in obsessive-compulsive disorder.Frontiers in psychiatry · 2024Article
- Will Transcranial Magnetic Stimulation Improve the Treatment of Obsessive-Compulsive Disorder? A Systematic Review and Meta-Analysis of Current Targets and Clinical Evidence.Life (Basel, Switzerland) · 2023Review
- Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials.Brain sciences · 2022Review
- Neuromodulation of OCD: A review of invasive and non-invasive methods.Frontiers in neurology · 2022Review
- Case report: Improved behavioral and psychiatric symptoms with repetitive transcranial magnetic stimulation at the bilateral DLPFC combined with cognitive and behavioral therapy in a patient with unilateral thalamic hemorrhage.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Antoine PelissoloAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa). antoine.pelissolo@inserm.fr.
Ghina Harika-GermaneauAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Fady RachidAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Christian Gaudeau-BosmaAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Marie-Laure TanguyAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Rene BenAdhiraAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Noomane BouazizAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Traian PopaAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Issa WassoufAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Ghassen SabaAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Dominique JanuelAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Nematollah JaafariAP-HP, service de psychiatrie, Hôpital Henri-Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France (Drs Pelissolo and Saba); Unité de recherche clinique en psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire expérimental et clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France (Drs Harika-Germaneau, Rachid, Wassouf, and Jaafari); Unité de Recherche Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France (Dr Tanguy); Unité de Recherche Clinique, EPS Ville-Evrard, Neuilly-sur-Marne, France (Drs Gaudeau, Benadhira, Bouaziz, and Januel); Institut du Cerveau et de la Moëlle Epinière (ICM), Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie - UMR S975, Paris, France (Dr Popa).
Centre National de la Recherche Scientifique · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRepetitive transcranial magnetic stimulation has been explored in patients with obsessive-compulsive disorder, but with negative or conflicting results. This randomized double-blind study was designed to assess the efficacy of 1-Hz repetitive transcranial magnetic stimulation over the presupplementary area.
methodsForty medication-resistant patients were assigned to 4 weeks of either active or sham repetitive transcranial magnetic stimulation targeting the presupplementary area with the help of a neuronavigation system.
resultsAccording to the Yale-Brown obsessive-compulsive scale, the baseline-week 4 evolution showed no significant differences between groups. Responder rates at week 4 were not different between groups (repetitive transcranial magnetic stimulation 10.5% vs sham 20%; P=.63).
conclusionLow-frequency repetitive transcranial magnetic stimulation applied to the presupplementary area seems ineffective for the treatment of obsessive-compulsive disorder patients, at least in severe and drug-refractory cases such as those included in this study. Further research is required to determine profiles of responder patients and appropriate repetitive transcranial magnetic stimulation parameters for obsessive-compulsive disorder.
Indexed as
Transcranial Magnetic StimulationAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedMotor CortexObsessive-Compulsive DisorderTreatment OutcomeYoung Adultobsessive-compulsive disorderrepetitive transcranial magnetic stimulationSMAtreatment
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.