Evidence map›Paper›PMID 27207918›Full record

ArticleThe international journal of neuropsychopharmacology2016

Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel.

Miri Gitik, Vibhuti Srivastava, Colin A Hodgkinson, Pei-Hong Shen, David Goldman, Dieter J Meyerhoff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Miri GitikLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland (Drs Gitik, Srivastava, and Hodgkinson, Ms Shen, and Dr Goldman); Department of Radiology and Biomedical Imaging, University of California, San Francisco, California (Dr Meyerhoff); Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, California (Dr Meyerhoff).Current address (V.S.): Molecular Genetic Technology Program, School of Health Professions, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
Vibhuti SrivastavaLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland (Drs Gitik, Srivastava, and Hodgkinson, Ms Shen, and Dr Goldman); Department of Radiology and Biomedical Imaging, University of California, San Francisco, California (Dr Meyerhoff); Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, California (Dr Meyerhoff).Current address (V.S.): Molecular Genetic Technology Program, School of Health Professions, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
Colin A HodgkinsonLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland (Drs Gitik, Srivastava, and Hodgkinson, Ms Shen, and Dr Goldman); Department of Radiology and Biomedical Imaging, University of California, San Francisco, California (Dr Meyerhoff); Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, California (Dr Meyerhoff).Current address (V.S.): Molecular Genetic Technology Program, School of Health Professions, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
Pei-Hong ShenLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland (Drs Gitik, Srivastava, and Hodgkinson, Ms Shen, and Dr Goldman); Department of Radiology and Biomedical Imaging, University of California, San Francisco, California (Dr Meyerhoff); Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, California (Dr Meyerhoff).Current address (V.S.): Molecular Genetic Technology Program, School of Health Professions, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
David GoldmanLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland (Drs Gitik, Srivastava, and Hodgkinson, Ms Shen, and Dr Goldman); Department of Radiology and Biomedical Imaging, University of California, San Francisco, California (Dr Meyerhoff); Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, California (Dr Meyerhoff).Current address (V.S.): Molecular Genetic Technology Program, School of Health Professions, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
Dieter J MeyerhoffLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland (Drs Gitik, Srivastava, and Hodgkinson, Ms Shen, and Dr Goldman); Department of Radiology and Biomedical Imaging, University of California, San Francisco, California (Dr Meyerhoff); Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, California (Dr Meyerhoff).Current address (V.S.): Molecular Genetic Technology Program, School of Health Professions, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030. dieter.meyerhoff@ucsf.edu.
National Institute on Alcohol Abuse and Alcoholism · USSan Francisco VA Medical Center · USUniversity of California, San Francisco · US

Funding

Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
The Biological Basis of Alcohol Induced Brain DamageR01AA010788 · NIAAA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MEYERHOFF, DIETER J · 1996 to 2016
$8.9M
Polysubstance Use and Chronic Smoking: Neuroimaging and CognitionR21DA025202 · NIDA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MEYERHOFF, DIETER J · 2009 to 2010
$426k
NIAAA NIH HHS R01 AA010788NIDA NIH HHS R21 DA025202
6 · The paper itself

Abstract

backgroundReduction in brain volume, especially gray matter volume, has been shown to be one of the many deleterious effects of prolonged alcohol consumption. High variance in the degree of gray matter tissue shrinkage among alcohol-dependent individuals and a previous neuroimaging genetics report suggest the involvement of environmental and/or genetic factors, such as superoxide dismutase 2 (SOD2). Identification of such underlying factors will help in the clinical management of alcohol dependence.

methodsWe analyzed quantitative magnetic resonance imaging and genotype data from 103 alcohol users, including both light drinkers and treatment-seeking alcohol-dependent individuals. Genotyping was performed using a custom gene array that included genes selected from 8 pathways relevant to chronic alcohol-related brain volume loss.

resultsWe replicated a significant association of a functional SOD2 single nucleotide polymorphism with normalized gray matter volume, which had been reported previously in an independent smaller sample of alcohol-dependent individuals. The SOD2-related genetic protection was observed only at the cohort's lower drinking range. Additional associations between normalized gray matter volume and other candidate genes such as alcohol dehydrogenase gene cluster (ADH), GCLC, NOS3, and SYT1 were observed across the entire sample but did not survive corrections for multiple comparisons.

conclusionConverging independent evidence for a SOD2 gene association with gray matter volume shrinkage in chronic alcohol users suggests that SOD2 genetic variants predict differential brain volume loss mediated by free radicals. This study also provides the first catalog of genetic variations relevant to gray matter loss in chronic alcohol users. The identified gene-brain structure relationships are functionally pertinent and merit replication.

Indexed as

Alcohol use disordergeneticsgray matter volumeneuroimagingsuperoxide dismutase 2 (SOD2)

Identifiers

PMID27207918
PMCPMC5043642
OpenAlexW2341039899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.