ArticleDiabetes2016
Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents.
Article in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- Trial
- Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.Scientific reports · 2017Trial
- fNIRS estimates prefrontal cortex activation following glucose load in youths with obesity.Journal of endocrinological investigation · 2026Article
- Altered hypothalamic functional connectivity in adolescents with severe obesity.International journal of obesity (2005) · 2026Observational
- Advances in Research on Childhood-Obesity Associated With Gestational Diabetes Mellitus.Journal of diabetes · 2026Review
- Altered Hypothalamic functional connectivity in adolescents with severe obesity.Research square · 2026Article
- Weight Loss After Obesity Disrupts Cognitive Flexibility Through Reinforcement Learning Strategies.Obesity (Silver Spring, Md.) · 2026Article
- Adherence to the Mediterranean Diet and Its Association with Cognitive Function in Children and Adolescents: A Systematic Review of Observational Studies.Children (Basel, Switzerland) · 2025Review
- Abstinence-based treatment of comorbid eating disorders and ultra-processed food addiction.Frontiers in psychiatry · 2025Article
- The battle over "food addiction".Frontiers in psychiatry · 2025Review
- Reprogramming energy homeostasis in children with overweight through cognitive training and social interaction. A study protocol to estimate leptin sensitivity.Frontiers in endocrinology · 2025Article
- Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Effects of aerobic exercise training in oxidative metabolism and mitochondrial biogenesis markers on prefrontal cortex in obese mice.BMC sports science, medicine & rehabilitation · 2022Article
- Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats.JCI insight · 2022Article
- FGF21 response to sucrose is associated with BMI and dorsal striatal signaling in humans.Obesity (Silver Spring, Md.) · 2022Article
- Intergenerational transmission of parental risky health behaviors in Chinese children: Are there socioeconomic status differences?Frontiers in medicine · 2022Article
- How Impulsiveness Influences Obesity: The Mediating Effect of Resting-State Brain Activity in the dlPFC.Frontiers in psychiatry · 2022Article
- Brain responses to glucose ingestion are greater in children than adults and are associated with overweight and obesity.Obesity (Silver Spring, Md.) · 2021Article
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15 authors at 1 institution in 1 country.
Funding
Abstract
Increased sugar-sweetened beverage consumption has been linked to higher rates of obesity. Using functional MRI, we assessed brain perfusion responses to drinking two commonly consumed monosaccharides, glucose and fructose, in obese and lean adolescents. Marked differences were observed. In response to drinking glucose, obese adolescents exhibited decreased brain perfusion in brain regions involved in executive function (prefrontal cortex [PFC]) and increased perfusion in homeostatic appetite regions of the brain (hypothalamus). Conversely, in response to drinking glucose, lean adolescents demonstrated increased PFC brain perfusion and no change in perfusion in the hypothalamus. In addition, obese adolescents demonstrated attenuated suppression of serum acyl-ghrelin and increased circulating insulin level after glucose ingestion; furthermore, the change in acyl-ghrelin and insulin levels after both glucose and fructose ingestion was associated with increased hypothalamic, thalamic, and hippocampal blood flow in obese relative to lean adolescents. Additionally, in all subjects there was greater perfusion in the ventral striatum with fructose relative to glucose ingestion. Finally, reduced connectivity between executive, homeostatic, and hedonic brain regions was observed in obese adolescents. These data demonstrate that obese adolescents have impaired prefrontal executive control responses to drinking glucose and fructose, while their homeostatic and hedonic responses appear to be heightened. Thus, obesity-related brain adaptations to glucose and fructose consumption in obese adolescents may contribute to excessive consumption of glucose and fructose, thereby promoting further weight gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.