ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2016
Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-κB signaling pathway.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- miR‑16‑5p Protects RGCs Against Retinal Ischemia-Reperfusion Injury by Modulating Astrocyte-Mediated Neuroinflammation Through the Wip1/NF-κB Signaling Axis.Molecular neurobiology · 2026Article
- Effect of astrocyte GPER on the optic nerve inflammatory response following optic nerve injury in mice.Heliyon · 2024Article
- Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly.Cell death discovery · 2023Review
- Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia.Stroke and vascular neurology · 2021Article
- Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush.Molecular biology reports · 2020Article
- Blocking VEGF signaling augments interleukin-8 secretionInternational journal of ophthalmology · 2020Article
- Caffeic acid phenethyl ester attenuates nuclear factor‑κB‑mediated inflammatory responses in Müller cells and protects against retinal ganglion cell death.Molecular medicine reports · 2019Article
- Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond.International journal of molecular sciences · 2018Review
- Expression, distribution and function of kinin BBritish journal of pharmacology · 2018Article
- Interaction of Wip1 and NF-κB regulates neuroinflammatory response in astrocytes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Expression of wild-type p53-induced phosphatase 1 in diabetic epiretinal membranes.Oncotarget · 2017Article
- DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation.Cell death discovery · 2017Review
- Phosphatase Wip1 in Immunity: An Overview and Update.Frontiers in immunology · 2017Review
- Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the expression and possible roles of Wip1 in retinal astrocytes after optic nerve crush (ONC).
methodsExpressions of Wip1, GFAP, and p-p65 in ONC model were analyzed by Western blot and immunofluorescence. The mRNA expressions of the pro-inflammatory cytokines (IL-8, TNF-α, IL-6 and IL-1β) were analyzed by RT-PCR.
resultsWip1 was up-regulated at 14 days after ONC by Western blot and immunofluorescence. The changes of Wip1 were striking in astrocytes. Furthermore, the protein expression level of p-p65 was paralleled with Wip1 in a time-dependent manner by ONC. In addition, co-localization of Wip1 with Phospho-NF-κB-p65 (p-p65) was detected. Finally, the mRNA expressions of the pro-inflammatory cytokines (IL-8, TNF-α, IL-6 and IL-1β) were significantly increased in retina after ONC.
conclusionsThese data were consistent with the hypothesis that Wip1 was implicated in neuroinflammation of retinal astrocytes after ONC via NF-κB signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.