ArticleAnnals of intensive care2016
High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study.
Article in Annals of intensive care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04368325 (A Correlation of Low Serum Creatinine Levels and Respiratory Function in the Mechanically Ventilated Patients in the Intensive Care Unit), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Correlation of Low Serum Creatinine Levels and Respiratory Function in the Mechanically Ventilated Patients in the Intensive Care Unit
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- The Impact of High-Flow Nasal Cannula on the Outcome of Immunocompromised Patients with Acute Respiratory Failure: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- A Systematic Review of the High-flow Nasal Cannula for Adult Patients.Critical care (London, England) · 2018Pooled it
- Use of noninvasive ventilation in immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis.Critical care (London, England) · 2017Pooled it
- Comparison of clinical outcomes between non-invasive ventilation and high-flow nasal cannula use in patients with acute pancreatitis.BMC pulmonary medicine · 2026Article
- Patterns and outcomes of real-world high-flow nasal cannula use: a multi-hospital retrospective cohort study.Critical care science · 2026Observational
- Review
- Article
- Comparison of high-flow nasal oxygen therapy and noninvasive ventilation in suspected sepsis patients with acute respiratory distress in the emergency department: a retrospective cohort study.International journal of emergency medicine · 2025Article
- Association between arterial oxygen and mortality across critically ill patients with hematologic malignancies: results from an international collaborative network.Intensive care medicine · 2024Article
- High-Flow Nasal Cannula Oxygen Therapy versus Non-Invasive Ventilation in AIDS Patients with Acute Respiratory Failure: A Randomized Controlled Trial.Journal of clinical medicine · 2023Article
- Application of high-flow oxygen therapy in acute pancreatitis complicated with acute respiratory dysfunction.Turkish journal of medical sciences · 2022Article
- Article
- Recent advances in the use of high flow nasal oxygen therapies.Frontiers in medicine · 2022Review
- Design and engineering application of medical oxygen supply system in novel coronavirus pneumonia treatment hospital.Journal of building engineering · 2021Article
- High flow nasal cannula for adult acute hypoxemic respiratory failure in the ED setting.The American journal of emergency medicine · 2021Review
- High-flow nasal cannula for respiratory failure in adult patients.Acute and critical care · 2021Article
- High-Flow Nasal Oxygen Therapy in Acute Hypoxemic Respiratory Failure: Concise Review on Technology and Initial Methodology.Turkish thoracic journal · 2021Article
- Oxygenation strategy during acute respiratory failure in immunocompromised patients.Journal of intensive medicine · 2021Review
- Observational
- Use of nasal high flow oxygen during acute respiratory failure.Intensive care medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory failure is the main cause of admission to intensive care unit in immunocompromised patients. In this subset of patients, the beneficial effects of noninvasive ventilation (NIV) as compared to standard oxygen remain debated. High-flow nasal cannula oxygen therapy (HFNC) is an alternative to standard oxygen or NIV, and its use in hypoxemic patients has been growing. Therefore, we aimed to compare outcomes of immunocompromised patients treated using HFNC alone or NIV as a first-line therapy for acute respiratory failure in an observational cohort study over an 8-year period. Patients with acute-on-chronic respiratory failure, those treated with standard oxygen alone or needing immediate intubation, and those with a do-not-intubate order were excluded.
resultsAmong the 115 patients analyzed, 60 (52 %) were treated with HFNC alone and 55 (48 %) with NIV as first-line therapy with 30 patients (55 %) receiving HFNC and 25 patients (45 %) standard oxygen between NIV sessions. The rates of intubation and 28-day mortality were higher in patients treated with NIV than with HFNC (55 vs. 35 %, p = 0.04, and 40 vs. 20 %, p = 0.02 log-rank test, respectively). Using propensity score-matched analysis, NIV was associated with mortality. Using multivariate analysis, NIV was independently associated with intubation and mortality.
conclusionsBased on this observational cohort study including immunocompromised patients admitted to intensive care unit for acute respiratory failure, intubation and mortality rates could be lower in patients treated with HFNC alone than with NIV. The use of NIV remained independently associated with poor outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.